Literature DB >> 15380176

Upfront submandibular salivary gland transfer in pharyngeal cancers.

K A Pathak1, R L Bhalavat, R C Mistry, M S Deshpande, V Bhalla, S B Desai, B L Malpani.   

Abstract

Head and neck irradiation results in salivary dysfunction and subsequent xerostomia. Twenty two patients with squamous cancer of oropharynx or hypopharynx underwent contralateral submandibular salivary gland transfer (SMSGT) to submental triangle to shield it from subsequent radiotherapy. Resting salivary outputs of transferred and untransferred gland (control) were measured before and after SMSGT and following radiotherapy, by cannulating individual submandibular duct. They were compared by paired samples t-test. Following radiation therapy transferred gland retained 73% and untransferred gland (control) retained 27% of baseline salivary output. This significant difference in post-radiation salivary outputs suggests preservation of function of transferred salivary gland.

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Year:  2004        PMID: 15380176     DOI: 10.1016/j.oraloncology.2004.04.016

Source DB:  PubMed          Journal:  Oral Oncol        ISSN: 1368-8375            Impact factor:   5.337


  5 in total

Review 1.  A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact.

Authors:  S B Jensen; A M L Pedersen; A Vissink; E Andersen; C G Brown; A N Davies; J Dutilh; J S Fulton; L Jankovic; N N F Lopes; A L S Mello; L V Muniz; C A Murdoch-Kinch; R G Nair; J J Napeñas; A Nogueira-Rodrigues; D Saunders; B Stirling; I von Bültzingslöwen; D S Weikel; L S Elting; F K L Spijkervet; M T Brennan
Journal:  Support Care Cancer       Date:  2010-03-25       Impact factor: 3.603

2.  A phase II study of submandibular gland transfer prior to radiation for prevention of radiation-induced xerostomia in head-and-neck cancer (RTOG 0244).

Authors:  Naresh Jha; Jonathan Harris; Hadi Seikaly; John R Jacobs; A J B McEwan; K Thomas Robbins; John Grecula; Anand K Sharma; K Kian Ang
Journal:  Int J Radiat Oncol Biol Phys       Date:  2012-04-27       Impact factor: 7.038

3.  Salivary gland-sparing other than parotid-sparing in definitive head-and-neck intensity-modulated radiotherapy does not seem to jeopardize local control.

Authors:  Enrique Chajon; Caroline Lafond; Guillaume Louvel; Joël Castelli; Danièle Williaume; Olivier Henry; Franck Jégoux; Elodie Vauléon; Jean-Pierre Manens; Elisabeth Le Prisé; Renaud de Crevoisier
Journal:  Radiat Oncol       Date:  2013-05-30       Impact factor: 3.481

4.  Disruption of tight junctions contributes to hyposalivation of salivary glands in a mouse model of type 2 diabetes.

Authors:  Yan Huang; Qian-Ying Mao; Xi-Jin Shi; Xin Cong; Yan Zhang; Li-Ling Wu; Guang-Yan Yu; Ruo-Lan Xiang
Journal:  J Anat       Date:  2020-05-06       Impact factor: 2.921

Review 5.  Radiation-Induced Salivary Gland Dysfunction: Mechanisms, Therapeutics and Future Directions.

Authors:  Kimberly J Jasmer; Kristy E Gilman; Kevin Muñoz Forti; Gary A Weisman; Kirsten H Limesand
Journal:  J Clin Med       Date:  2020-12-18       Impact factor: 4.964

  5 in total

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