Literature DB >> 15380098

The mechanism of non-homologous end-joining: a synopsis of synapsis.

Eric Weterings1, Dik C van Gent.   

Abstract

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends.

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Year:  2004        PMID： 15380098     DOI： 10.1016/j.dnarep.2004.06.003

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  71 in total

1.  Characterization of the roles of the catalytic domains of Mycobacterium tuberculosis ligase D in Ku-dependent error-prone DNA end joining.

Authors:  Douglas Wright; Austin DeBeaux; Runhua Shi; Aidan J Doherty; Lynn Harrison
Journal:  Mutagenesis       Date:  2010-06-07       Impact factor: 3.000

Review 2.  DNA damage response.

Authors:  Giuseppina Giglia-Mari; Angelika Zotter; Wim Vermeulen
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-01-01       Impact factor: 10.005

Review 3.  DNA-PK: a dynamic enzyme in a versatile DSB repair pathway.

Authors:  Anthony J Davis; Benjamin P C Chen; David J Chen
Journal:  DNA Repair (Amst)       Date:  2014-03-27

4.  Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.

Authors:  Michal Schwartz; Eitan Zlotorynski; Michal Goldberg; Efrat Ozeri; Ayelet Rahat; Carlos le Sage; Benjamin P C Chen; David J Chen; Reuven Agami; Batsheva Kerem
Journal:  Genes Dev       Date:  2005-11-15       Impact factor: 11.361

5.  A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

Authors:  Mirjam van der Burg; Hanna Ijspeert; Nicole S Verkaik; Tuba Turul; Wouter W Wiegant; Keiko Morotomi-Yano; Pierre-Olivier Mari; Ilhan Tezcan; David J Chen; Malgorzata Z Zdzienicka; Jacques J M van Dongen; Dik C van Gent
Journal:  J Clin Invest       Date:  2008-12-15       Impact factor: 14.808

6.  The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.

Authors:  Anthony J Davis; Kyung-Jong Lee; David J Chen
Journal:  J Biol Chem       Date:  2013-01-15       Impact factor: 5.157

7.  Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo.

Authors:  Jing-Jing Li; Qi-Hua Gu; Min Li; Hua-Ping Yang; Li-Ming Cao; Cheng-Ping Hu
Journal:  Oncol Lett       Date:  2012-10-16       Impact factor: 2.967

8.  CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.

Authors:  Chitra Subramanian; Manila Hada; Anthony W Opipari; Valerie P Castle; Roland P S Kwok
Journal:  Mol Cancer Res       Date:  2012-12-05       Impact factor: 5.852

9.  Efficient repair of DNA double-strand breaks in malignant cells with structural instability.

Authors:  Yue Cheng; Zhenhua Zhang; Bridget Keenan; Anna V Roschke; Kenneth Nakahara; Peter D Aplan
Journal:  Mutat Res       Date:  2010-01-05       Impact factor: 2.433

Review 10.  Evolution in health and medicine Sackler colloquium: Genomic disorders: a window into human gene and genome evolution.

Authors:  Claudia M B Carvalho; Feng Zhang; James R Lupski
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-13       Impact factor: 11.205
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