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Literature DB >> 15380094

Mechanisms and molecules of the mitotic spindle.

Abstract

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is required for the faithful transmission of the genome to the two daughter cells during division. This process is facilitated by the intrinsic polarity and dynamic properties of microtubules and involves many proteins that modulate microtubule organization and stability. Recent work has begun to uncover the molecular mechanisms behind these dynamic events. Here we describe current models and discuss some of the complex repertoire of factors required for spindle assembly and chromosome segregation.

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Year: 2004 PMID： 15380094 DOI： 10.1016/j.cub.2004.09.021

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

137 in total

Mechanisms and molecules of the mitotic spindle.

1. The centrosome and bipolar spindle assembly: does one have anything to do with the other?

2. Mechanical impulses can control metaphase progression in a mammalian cell.

3. RNA in centrosomes: structure and possible functions.

4. c-Src but not Fyn promotes proper spindle orientation in early prometaphase.

5. Phospho-regulation of DDA3 function in mitosis.

6. PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity.

7. RNA- binding protein Stau2 is important for spindle integrity and meiosis progression in mouse oocytes.

8. Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex.

9. The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.

10. Aurora A, mitotic entry, and spindle bipolarity.