| Literature DB >> 15379751 |
P G McGlinchey1, M S Spence, C C Patterson, A R Allen, G Murphy, C Belton, P P McKeown.
Abstract
The possible role of the K469E polymorphism in the intercellular adhesion molecule-1 (ICAM-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family-based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped for the ICAM-1 K469E polymorphism. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the ICAM-1 K469E polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the ICAM-1 K469E polymorphism is not associated with IHD.Entities:
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Year: 2004 PMID： 15379751 DOI： 10.1111/j.1365-2370.2004.00474.x
Source DB: PubMed Journal: Eur J Immunogenet ISSN： 0960-7420