Literature DB >> 15378034

Molecular structure of human geminin.

Andrei L Okorokov1, Elena V Orlova, Sarah R Kingsbury, Claire Bagneris, Ulrich Gohlke, Gareth H Williams, Kai Stoeber.   

Abstract

The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 A. The geminin molecule is a tetramer formed by two dimers with monomers interacting via coiled-coil domains. The unusual structural organization of geminin provides molecular insight into its bifunctional nature.

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Year:  2004        PMID： 15378034     DOI： 10.1038/nsmb835

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  9 in total

1.  Regulation of geminin functions by cell cycle-dependent nuclear-cytoplasmic shuttling.

Authors:  Lingfei Luo; Yvonne Uerlings; Nicole Happel; Naisana S Asli; Hendrik Knoetgen; Michael Kessel
Journal:  Mol Cell Biol       Date:  2007-04-30       Impact factor: 4.272

2.  A Cdt1-geminin complex licenses chromatin for DNA replication and prevents rereplication during S phase in Xenopus.

Authors:  Malik Lutzmann; Domenico Maiorano; Marcel Méchali
Journal:  EMBO J       Date:  2006-11-23       Impact factor: 11.598

3.  Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.

Authors:  Zhiying You; Koji L Ode; Mayumi Shindo; Haruhiko Takisawa; Hisao Masai
Journal:  Cell Cycle       Date:  2016-05-02       Impact factor: 4.534

Review 4.  Preventing re-replication of chromosomal DNA.

Authors:  J Julian Blow; Anindya Dutta
Journal:  Nat Rev Mol Cell Biol       Date:  2005-06       Impact factor: 94.444

5.  Functional domains of the Xenopus replication licensing factor Cdt1.

Authors:  Andrew Ferenbach; Anatoliy Li; Marta Brito-Martins; J Julian Blow
Journal:  Nucleic Acids Res       Date:  2005-01-13       Impact factor: 16.971

6.  SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.

Authors:  Jian Ma; Qing Shi; Gaofeng Cui; Haoyue Sheng; Maria Victoria Botuyan; Yingke Zhou; Yuqian Yan; Yundong He; Liguo Wang; Yuzhuo Wang; Georges Mer; Dingwei Ye; Chenji Wang; Haojie Huang
Journal:  Nat Commun       Date:  2021-10-01       Impact factor: 14.919

7.  Three-dimensional structure of CaV3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture.

Authors:  Conor P Walsh; Anthony Davies; Adrian J Butcher; Annette C Dolphin; Ashraf Kitmitto
Journal:  J Biol Chem       Date:  2009-06-11       Impact factor: 5.157

8.  Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer.

Authors:  Eva Torreira; Guy Schoehn; Yolanda Fernández; Núria Jorba; Rob W H Ruigrok; Stephen Cusack; Juan Ortín; Oscar Llorca
Journal:  Nucleic Acids Res       Date:  2007-05-21       Impact factor: 16.971

Review 9.  Control of DNA Replication Initiation by Ubiquitin.

Authors:  Esperanza Hernández-Carralero; Elisa Cabrera; Ignacio Alonso-de Vega; Santiago Hernández-Pérez; Veronique A J Smits; Raimundo Freire
Journal:  Cells       Date:  2018-09-20       Impact factor: 6.600
  9 in total

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