Literature DB >> 15377875

MPTP as a mitochondrial neurotoxic model of Parkinson's disease.

Serge Przedborski1, Kim Tieu, Celine Perier, Miquel Vila.   

Abstract

1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review.

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Year:  2004        PMID： 15377875     DOI： 10.1023/B:JOBB.0000041771.66775.d5

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  46 in total

1.  The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase.

Authors:  R R Ramsay; A T Kowal; M K Johnson; J I Salach; T P Singer
Journal:  Arch Biochem Biophys       Date:  1987-12       Impact factor: 4.013

2.  Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on ATP levels of mouse brain synaptosomes.

Authors:  K P Scotcher; I Irwin; L E DeLanney; J W Langston; D Di Monte
Journal:  J Neurochem       Date:  1990-04       Impact factor: 5.372

3.  Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain.

Authors:  P Chan; L E DeLanney; I Irwin; J W Langston; D Di Monte
Journal:  J Neurochem       Date:  1991-07       Impact factor: 5.372

4.  Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Authors:  T P Singer; N Castagnoli; R R Ramsay; A J Trevor
Journal:  J Neurochem       Date:  1987-07       Impact factor: 5.372

5.  D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease.

Authors:  Kim Tieu; Celine Perier; Casper Caspersen; Peter Teismann; Du-Chu Wu; Shi-Du Yan; Ali Naini; Miquel Vila; Vernice Jackson-Lewis; Ravichandran Ramasamy; Serge Przedborski
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

6.  Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Authors:  K Chiba; L A Peterson; K P Castagnoli; A J Trevor; N Castagnoli
Journal:  Drug Metab Dispos       Date:  1985 May-Jun       Impact factor: 3.922

Review 7.  Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

Authors:  R E Heikkila; B A Sieber; L Manzino; P K Sonsalla
Journal:  Mol Chem Neuropathol       Date:  1989-06

8.  Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode.

Authors:  G P Davey; K F Tipton; M P Murphy
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

9.  Specificity of pyridinium inhibitors of the ubiquinone reduction sites in mitochondrial complex I.

Authors:  H Miyoshi; J Iwata; K Sakamoto; H Furukawa; M Takada; H Iwamura; T Watanabe; Y Kodama
Journal:  J Biol Chem       Date:  1998-07-10       Impact factor: 5.157

10.  Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

Authors:  R R Ramsay; T P Singer
Journal:  J Biol Chem       Date:  1986-06-15       Impact factor: 5.157
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  114 in total

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Authors:  Bin Zheng; Zhixiang Liao; Joseph J Locascio; Kristen A Lesniak; Sarah S Roderick; Marla L Watt; Aron C Eklund; Yanli Zhang-James; Peter D Kim; Michael A Hauser; Edna Grünblatt; Linda B Moran; Silvia A Mandel; Peter Riederer; Renee M Miller; Howard J Federoff; Ullrich Wüllner; Spyridon Papapetropoulos; Moussa B Youdim; Ippolita Cantuti-Castelvetri; Anne B Young; Jeffery M Vance; Richard L Davis; John C Hedreen; Charles H Adler; Thomas G Beach; Manuel B Graeber; Frank A Middleton; Jean-Christophe Rochet; Clemens R Scherzer
Journal:  Sci Transl Med       Date:  2010-10-06       Impact factor: 17.956

2.  Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization.

Authors:  Judith Eschbach; Björn von Einem; Kathrin Müller; Hanna Bayer; Annika Scheffold; Bradley E Morrison; K Lenhard Rudolph; Dietmar R Thal; Anke Witting; Patrick Weydt; Markus Otto; Michael Fauler; Birgit Liss; Pamela J McLean; Albert R La Spada; Albert C Ludolph; Jochen H Weishaupt; Karin M Danzer
Journal:  Ann Neurol       Date:  2014-12-19       Impact factor: 10.422

3.  The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.

Authors:  E Ilijic; J N Guzman; D J Surmeier
Journal:  Neurobiol Dis       Date:  2011-04-16       Impact factor: 5.996

4.  Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

Authors:  Chee Yeun Chung; Hyemyung Seo; Kai Christian Sonntag; Andrew Brooks; Ling Lin; Ole Isacson
Journal:  Hum Mol Genet       Date:  2005-05-11       Impact factor: 6.150

5.  Effects of mitochondrial toxins on the brain amino acid concentrations.

Authors:  Peter Klivenyi; Katalin A Kekesi; Zsuzsanna Hartai; Gabor Juhasz; Laszlo Vecsei
Journal:  Neurochem Res       Date:  2005-11       Impact factor: 3.996

6.  Time-course of brain oxidative damage caused by intrastriatal administration of 6-hydroxydopamine in a rat model of Parkinson's disease.

Authors:  Sofía Sánchez-Iglesias; Pablo Rey; Estefanía Méndez-Alvarez; José Luis Labandeira-García; Ramón Soto-Otero
Journal:  Neurochem Res       Date:  2006-12-12       Impact factor: 3.996

7.  Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells.

Authors:  Inês Fonseca; Gisela Gordino; Sara Moreira; Maria João Nunes; Carla Azevedo; Maria João Gama; Elsa Rodrigues; Cecília Maria Pereira Rodrigues; Margarida Castro-Caldas
Journal:  Mol Neurobiol       Date:  2016-10-03       Impact factor: 5.590

8.  Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

Authors:  Prachi Bajpai; Michelle C Sangar; Shilpee Singh; Weigang Tang; Seema Bansal; Goutam Chowdhury; Qian Cheng; Ji-Kang Fang; Martha V Martin; F Peter Guengerich; Narayan G Avadhani
Journal:  J Biol Chem       Date:  2012-12-20       Impact factor: 5.157

9.  Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture.

Authors:  Lyle Wiemerslage; Bradley J Schultz; Archan Ganguly; Daewoo Lee
Journal:  J Neurochem       Date:  2013-03-24       Impact factor: 5.372

Review 10.  Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function.

Authors:  Sunitha Bollimuntha; Biswaranjan Pani; Brij B Singh
Journal:  Adv Exp Med Biol       Date:  2017       Impact factor: 2.622
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