| Literature DB >> 15377844 |
Elisa Sensi1, Mariella Tancredi, Paolo Aretini, Giovanna Cipollini, Paola Collecchi, A Giuseppe Naccarato, Paolo Viacava, Generoso Bevilacqua, Maria A Caligo.
Abstract
GADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.Entities:
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Year: 2004 PMID： 15377844 DOI： 10.1023/B:BREA.0000041625.60280.4a
Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.872