K Singh1. 1. Department of Physiology, Post Graduate Institute of Medical Sciences, Rohtak.
Abstract
BACKGROUND: Smoking may predispose to ventricular fibrillation and sudden cardiac death by altering ventricular recovery time dispersion indices. However, effect of acute smoking on QT interval and QT dispersion in chronic smokers has not been studied so far. METHODS AND RESULTS: Effect of cigarette smoking on ventricular recovery time dispersion indices and rate pressure product (product of heart rate and systolic blood pressure) was investigated in 25 chronic smokers and compared with 25 age- and sex-matched non-smoker controls. There was increase in R-R interval (p<0.05). corrected QT interval, QT dispersion (p<0.001) and rate pressure product (p<0.05) in chronic smokers at baseline (before smoking) compared to non-smoker controls. On cigarette smoking, there was further increase in heart rate, blood pressure, QT dispersion and rate pressure product (p<0.001) with reduction in R-R interval (p<0.05) in chronic smokers compared to non-smoker controls. CONCLUSIONS: Our observations indicate that there may be some relationship between prolonged ventricular recovery time dispersion indices and ventricular fibrillation and sudden cardiac death associated with smoking.
BACKGROUND: Smoking may predispose to ventricular fibrillation and sudden cardiac death by altering ventricular recovery time dispersion indices. However, effect of acute smoking on QT interval and QT dispersion in chronic smokers has not been studied so far. METHODS AND RESULTS: Effect of cigarette smoking on ventricular recovery time dispersion indices and rate pressure product (product of heart rate and systolic blood pressure) was investigated in 25 chronic smokers and compared with 25 age- and sex-matched non-smoker controls. There was increase in R-R interval (p<0.05). corrected QT interval, QT dispersion (p<0.001) and rate pressure product (p<0.05) in chronic smokers at baseline (before smoking) compared to non-smoker controls. On cigarette smoking, there was further increase in heart rate, blood pressure, QT dispersion and rate pressure product (p<0.001) with reduction in R-R interval (p<0.05) in chronic smokers compared to non-smoker controls. CONCLUSIONS: Our observations indicate that there may be some relationship between prolonged ventricular recovery time dispersion indices and ventricular fibrillation and sudden cardiac death associated with smoking.
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