Literature DB >> 15375548

Galectin-3 and cancer (Review).

Stéphane Califice1, Vincent Castronovo, Frédéric Van Den Brûle.   

Abstract

Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported. These observations lead to the recognition of galectin-3 as a diagnostic/prognostic marker for specific cancer types, such as thyroid and prostate. This review discusses the expression and cellular localization of galectin-3 in cancer cells, as well as its numerous functions in cancer cell biology, including cell-cell adhesion, cell-matrix interactions, growth regulation, apoptosis, angiogenesis and mRNA splicing.

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Year:  2004        PMID： 15375548

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  57 in total

1.  Mathematical modeling of K-Ras nanocluster formation on the plasma membrane.

Authors:  Tianhai Tian; Sarah J Plowman; Robert G Parton; Yoel Kloog; John F Hancock
Journal:  Biophys J       Date:  2010-07-21       Impact factor: 4.033

2.  Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of β-catenin in gastric cancer.

Authors:  Seok-Jun Kim; Ji-Young Shin; Teak-Chin Cheong; Il-Ju Choi; Yeon Su Lee; Seok Hee Park; Kyung-Hee Chun
Journal:  Clin Exp Metastasis       Date:  2011-07-13       Impact factor: 5.150

Review 3.  Nuclear transport of galectin-3 and its therapeutic implications.

Authors:  Tatsuyoshi Funasaka; Avraham Raz; Pratima Nangia-Makker
Journal:  Semin Cancer Biol       Date:  2014-03-19       Impact factor: 15.707

4.  Galectin-3 is a substrate for prostate specific antigen (PSA) in human seminal plasma.

Authors:  Sarika Saraswati; Ashley S Block; Mari K Davidson; Roger G Rank; Maha Mahadevan; Alan B Diekman
Journal:  Prostate       Date:  2011-02-01       Impact factor: 4.104

5.  Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes.

Authors:  J W Yang; S U Kang; E Engidawork; R Rodrigo; V Felipo; G Lubec
Journal:  Neurochem Res       Date:  2006-06-28       Impact factor: 3.996

6.  Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study.

Authors:  Vitaly Balan; Pratima Nangia-Makker; Ann G Schwartz; Young Suk Jung; Larry Tait; Victor Hogan; Tirza Raz; Yi Wang; Zeng Quan Yang; Gen Sheng Wu; Yongjun Guo; Huixiang Li; Judith Abrams; Fergus J Couch; Wilma L Lingle; Ricardo V Lloyd; Stephen P Ethier; Michael A Tainsky; Avraham Raz
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

7.  Immunochemiluminescent detection of galectin-3 in tumoral tissue from prostate.

Authors:  Jorge Luiz Araújo-Filho; Mário Ribeiro Melo-Junior; Eduardo Isidoro Carneiro Beltrão; Luiza Rayanna Amorim de Lima; Consuelo Barreto Lins Antunes; Luiz Bezerra de Carvalho
Journal:  Int J Clin Exp Pathol       Date:  2013-08-15

8.  Neo-glycopeptides: the importance of sugar core conformation in oxime-linked glycoprobes for interaction studies.

Authors:  Carmen Jiménez-Castells; Beatriz G de la Torre; David Andreu; Ricardo Gutiérrez-Gallego
Journal:  Glycoconj J       Date:  2008-08-01       Impact factor: 2.916

9.  Proteome serological determination of tumor-associated antigens in melanoma.

Authors:  Michael Forgber; Uwe Trefzer; Wolfram Sterry; Peter Walden
Journal:  PLoS One       Date:  2009-04-17       Impact factor: 3.240

10.  Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis.

Authors:  Annett Koch; Francoise Poirier; Ralf Jacob; Delphine Delacour
Journal:  Mol Biol Cell       Date:  2009-11-18       Impact factor: 4.138
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