Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ca2+ regulation and gene expression in normal brain aging.

Literature DB >> 15374673

Ca2+ regulation and gene expression in normal brain aging.

Emil C Toescu¹, Alexei Verkhratsky, Philip W Landfield.

Abstract

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

Entities: Chemical Gene

Mesh：

Substances：
Calcium

Year: 2004 PMID： 15374673 DOI： 10.1016/j.tins.2004.07.010

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

Keyword Cloud
Cited

74 in total

1. Why do hair cells and spiral ganglion neurons in the cochlea die during aging?

Authors: Philip Perez; Jianxin Bao
Journal: Aging Dis Date: 2011-04-28 Impact factor: 6.745

2. Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses.

Authors: Wayne Chadwick; Yu Zhou; Sung-Soo Park; Liyun Wang; Nicholas Mitchell; Matthew D Stone; Kevin G Becker; Bronwen Martin; Stuart Maudsley
Journal: PLoS One Date: 2010-12-17 Impact factor: 3.240

3. Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model.

Authors: Alessio Crestini; Paola Piscopo; Mariavittoria Iazeolla; Diego Albani; Roberto Rivabene; Gianluigi Forloni; Annamaria Confaloni
Journal: J Mol Neurosci Date: 2010-10-28 Impact factor: 3.444

Review 4. Normal brain ageing: models and mechanisms.

Authors: Emil C Toescu
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2005-12-29 Impact factor: 6.237

5. Morphological homeostasis in cortical dendrites.

Authors: Alexei V Samsonovich; Giorgio A Ascoli
Journal: Proc Natl Acad Sci U S A Date: 2006-01-17 Impact factor: 11.205

6. Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.

Authors: C M Norris; E M Blalock; O Thibault; L D Brewer; G V Clodfelter; N M Porter; P W Landfield
Journal: J Neurophysiol Date: 2006-08-16 Impact factor: 2.714

Review 7. Ageing and the brain.

Authors: R Peters
Journal: Postgrad Med J Date: 2006-02 Impact factor: 2.401