| Literature DB >> 153745 |
Abstract
alpha-Actinin isolated from bovine brain migrated on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis like muscle alpha-actinin with an apparent mol.wt. of 100000 and cross-reacted with antibodies to muscle alpha-actinin. Brain alpha-actinin modulated actin-myosin Mg2+-activated adenosine triphosphatase activity and, when bound by polystyrene particles, was found to bind muscle actin and tropomyosin from solution. Brain alpha-actinin, in conjunction with the other components of the contractile and relaxing complex, may play a role in the release of neurotransmitters from synaptic vesicles.Entities:
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Year: 1978 PMID: 153745 PMCID: PMC1186041 DOI: 10.1042/bj1750063
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857