OBJECTS: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. METHODS: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. CONCLUSION: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.
OBJECTS: A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity. METHODS: We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals. CONCLUSION: Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.
Authors: T Tihan; P G Fisher; J L Kepner; C Godfraind; R D McComb; P T Goldthwaite; P C Burger Journal: J Neuropathol Exp Neurol Date: 1999-10 Impact factor: 3.685
Authors: Jonathan A Forbes; Lola B Chambless; Jason G Smith; Curtis A Wushensky; Richard L Lebow; JoAnn Alvarez; Matthew M Pearson Journal: J Neurosurg Pediatr Date: 2011-02 Impact factor: 2.375
Authors: L L Linscott; A G Osborn; S Blaser; M Castillo; R H Hewlett; N Wieselthaler; S S Chin; J Krakenes; G L Hedlund; C L Sutton Journal: AJNR Am J Neuroradiol Date: 2008-08-13 Impact factor: 3.825