Literature DB >> 15372082

Antitoxins: novel strategies to target agents of bioterrorism.

G Jonah A Rainey1, John A T Young.   

Abstract

Never before has there been such a strong possibility that biological agents might be used indiscriminately on civilian populations. This review focuses on the use of antitoxins - antibodies, receptor decoys, dominant-negative inhibitors of translocation, small-molecule inhibitors and substrate analogues - to counteract those biological weapons for which toxins are an important mechanism of disease pathogenesis.

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Year:  2004        PMID: 15372082     DOI: 10.1038/nrmicro977

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN: 1740-1526            Impact factor:   60.633


  51 in total

1.  Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group.

Authors:  Feng Li; Irina Chvyrkova; Simon Terzyan; Nancy Wakeham; Robert Turner; Arun K Ghosh; Xuejun C Zhang; Jordan Tang
Journal:  Appl Microbiol Biotechnol       Date:  2012-01-25       Impact factor: 4.813

2.  Stable peptide inhibitors prevent binding of lethal and oedema factors to protective antigen and neutralize anthrax toxin in vivo.

Authors:  Alessandro Pini; Ylenia Runci; Chiara Falciani; Barbara Lelli; Jlenia Brunetti; Silvia Pileri; Monica Fabbrini; Luisa Lozzi; Claudia Ricci; Andrea Bernini; Fiorella Tonello; Federica Dal Molin; Paolo Neri; Neri Niccolai; Luisa Bracci
Journal:  Biochem J       Date:  2006-04-01       Impact factor: 3.857

3.  An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.

Authors:  Nam-Kyu Lim; Jung-Hwan Kim; Mee Sook Oh; Sangyoon Lee; Se-Yeon Kim; Keun-Soo Kim; Hyun-Jung Kang; Hyo Jeong Hong; Kyung-Soo Inn
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

4.  Polyvalent inhibitors of anthrax toxin that target host receptors.

Authors:  Saleem Basha; Prakash Rai; Vincent Poon; Arundhati Saraph; Kunal Gujraty; Mandy Y Go; Skanda Sadacharan; Mia Frost; Jeremy Mogridge; Ravi S Kane
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-28       Impact factor: 11.205

5.  A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo.

Authors:  Kalpana Surendranath; Anjali A Karande
Journal:  Clin Vaccine Immunol       Date:  2008-03-19

6.  Generation of high-titer neutralizing antibodies against botulinum toxins A, B, and E by DNA electrotransfer.

Authors:  C Trollet; Y Pereira; A Burgain; E Litzler; M Mezrahi; J Seguin; M Manich; M R Popoff; D Scherman; P Bigey
Journal:  Infect Immun       Date:  2009-02-23       Impact factor: 3.441

7.  Identification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screen.

Authors:  Paul G Wahome; Yan Bai; Lori M Neal; Jon D Robertus; Nicholas J Mantis
Journal:  Toxicon       Date:  2010-03-27       Impact factor: 3.033

8.  Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor.

Authors:  Shilpi Sharma; Diane Thomas; John Marlett; Marianne Manchester; John A T Young
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

Review 9.  Protein engineering: a new frontier for biological therapeutics.

Authors:  Peter H Tobin; David H Richards; Randolph A Callender; Corey J Wilson
Journal:  Curr Drug Metab       Date:  2014       Impact factor: 3.731

10.  Inhibition of anthrax protective antigen outside and inside the cell.

Authors:  Marina V Backer; Vimal Patel; Brian T Jehning; Kevin P Claffey; Vladimir A Karginov; Joseph M Backer
Journal:  Antimicrob Agents Chemother       Date:  2006-10-30       Impact factor: 5.191

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