| Literature DB >> 15372044 |
Zachary Lippman1, Rob Martienssen.
Abstract
Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution.Mesh：
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Year: 2004 PMID： 15372044 DOI： 10.1038/nature02875
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962