Literature DB >> 15371744

Insulin growth factor-1 protects against excitotoxicity in the rat striatum.

Carole Escartin1, Frédéric Boyer, Alexis-Pierre Bemelmans, Philippe Hantraye, Emmanuel Brouillet.   

Abstract

Recent findings demonstrated the neuroprotective effects of insulin-like growth factor 1 (IGF-1) in a cultured cell model of Huntington's disease. In the present study, we examined the potential neuroprotective effect of IGF-1 in vivo, in a rat model of Huntington's disease using the NMDA receptor agonist quinolinate. Continuous intracerebroventricular infusion of recombinant IGF-1 (0.25 microg/h for 2 days) in the rat brain, produced a significant 8-fold increase in striatal levels of the growth factor. Histological evaluation after intrastriatal injection of quinolinate showed that IGF-1 treatment significantly attenuated striatal degeneration. These results further support the therapeutic interest of IGF-1 in Huntington's disease.

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Year:  2004        PMID： 15371744     DOI： 10.1097/00001756-200410050-00022

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  5 in total

1.  Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.

Authors:  Sara J Tallaksen-Greene; Marianna Sadagurski; Li Zeng; Roseanne Mauch; Matthew Perkins; Varuna C Banduseela; Andrew P Lieberman; Richard A Miller; Henry L Paulson; Roger L Albin
Journal:  J Neurosci       Date:  2014-11-19       Impact factor: 6.167

Review 2.  Glutamate and neurotrophic factors in neuronal plasticity and disease.

Authors:  Mark P Mattson
Journal:  Ann N Y Acad Sci       Date:  2008-11       Impact factor: 5.691

3.  Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury.

Authors:  Shaun W Carlson; Kathryn E Saatman
Journal:  J Neurotrauma       Date:  2018-04-17       Impact factor: 5.269

Review 4.  Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.

Authors:  Gwenn A Garden; Albert R La Spada
Journal:  Cerebellum       Date:  2008       Impact factor: 3.847

5.  Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide.

Authors:  Sook-Eun Park; Marcus Lawson; Robert Dantzer; Keith W Kelley; Robert H McCusker
Journal:  J Neuroinflammation       Date:  2011-12-21       Impact factor: 8.322
  5 in total

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