I R Radford1. 1. Radiation Oncology Division, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia. ian.radford@petermac.org
Abstract
PURPOSE: To develop a model for the initiation of human tumourigenesis that is consistent with various observations that are difficult to reconcile with current models. CONCLUSIONS: A novel model of tumourigenesis was developed that includes three basic postulates: (1) tumourigenesis is initiated by recombinogenic DNA lesions, (2) potentially recombinogenic DNA lesions in transcribed regions of the genome can be converted into chromosomal rearrangements and (3) chromosomal rearrangements alone are insufficient for tumourigenesis but can initiate a mutator/recombinator phenotype.
PURPOSE: To develop a model for the initiation of human tumourigenesis that is consistent with various observations that are difficult to reconcile with current models. CONCLUSIONS: A novel model of tumourigenesis was developed that includes three basic postulates: (1) tumourigenesis is initiated by recombinogenic DNA lesions, (2) potentially recombinogenic DNA lesions in transcribed regions of the genome can be converted into chromosomal rearrangements and (3) chromosomal rearrangements alone are insufficient for tumourigenesis but can initiate a mutator/recombinator phenotype.
Authors: Z Kote-Jarai; A Salmon; T Mengitsu; M Copeland; A Ardern-Jones; I Locke; S Shanley; B Summersgill; Y-J Lu; J Shipley; R Eeles Journal: Br J Cancer Date: 2006-01-30 Impact factor: 7.640
Authors: An Xu; Lubomir B Smilenov; Peng He; Ken-ichi Masumura; Takehiko Nohmi; Zengliang Yu; Tom K Hei Journal: Environ Health Perspect Date: 2007-01 Impact factor: 9.031