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Literature DB >> 15369135

Establishment and characterization of a human gestational choriocarcinoma cell line (HOCC).

Isamu Ishiwata¹, Chieko Ishiwata, Akira Tsuiki, Kazushige Kiguchi, Hisashi Hashimoto, Hiroshi Ishikawa.

Abstract

Human gestational choriocarcinoma cell line (HOCC) was established from the mouse graft of choriocarcinoma. The HOCC cells were spindle or polygonal in shape and multi-nucleated giant cells, showing neoplastic and pleomorphic features. The cell proliferated stably, and the population doubling time was about 32 hours. The chromosome numbers showed a wide distribution of aneuploidy, the mode was in hypertriploid range and the marker chromosomes were recognized in the several generations. Heterotransplantation was easy, and subcutaneous transplantation of 1 X 10(7) cells in nude mouse formed a tumor composed of choriocarcinoma. It is most noteworthy characteristic of the cell line that it produced human chorionic gonadotropin (hCG) in an in vitro culture system and in vivo in nude mice.

Entities: CellLine Disease Gene Species

Mesh：

Substances：
Chorionic Gonadotropin

Year: 2004 PMID： 15369135 DOI： 10.1111/j.1749-0774.2004.tb00018.x

Source DB: PubMed Journal: Hum Cell ISSN： 0914-7470 Impact factor: 4.174

13 in total

1. Establishment and characterization of human choriocarcinoma cell line derived from a metastatic focus of a testicular mixed germ cell tumor.

Authors: I Ishiwata; C Ishiwata; M Soma; I Ono; T Nakaguchi; K Kiguchi; M Furusato; T Tachibana; H Hashimoto; H Ishikawa
Journal: Hum Cell Date: 1999-12 Impact factor: 4.174

2. Establishment and characterization of a subline predisposed to pulmonary metastasis from a human gestational choriocarcinoma cell line in nude mice.

Authors: K Kanazawa; S Adachi; N Yoshiya; S Honma; H Takahashi; S Takeuchi
Journal: Acta Obstet Gynecol Scand Date: 1989 Impact factor: 3.636

3. Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells.

Authors: Haruto Egawa; Hiroshi Fujiwara; Takeshi Hirano; Takahiro Nakayama; Toshihiro Higuchi; Keiji Tatsumi; Takahide Mori; Shingo Fujii
Journal: Hum Reprod Date: 2002-02 Impact factor: 6.918

4. The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro.

Authors: R A Pattillo; G O Gey
Journal: Cancer Res Date: 1968-07 Impact factor: 12.701

5. Isolation of hormone-producing clonal lines of human choriocarcinoma.

Authors: P O Kohler; W E Bridson
Journal: J Clin Endocrinol Metab Date: 1971-05 Impact factor: 5.958

6. Development and characterization of established cell lines from primary and metastatic regions of human endometrial adenocarcinoma.

Authors: I Ishiwata; S Nozawa; T Inoue; H Okumura
Journal: Cancer Res Date: 1977-06 Impact factor: 12.701

Establishment and characterization of a human gestational choriocarcinoma cell line (HOCC).

1. Establishment and characterization of human choriocarcinoma cell line derived from a metastatic focus of a testicular mixed germ cell tumor.

2. Establishment and characterization of a subline predisposed to pulmonary metastasis from a human gestational choriocarcinoma cell line in nude mice.

3. Peripheral blood mononuclear cells in early pregnancy promote invasion of human choriocarcinoma cell line, BeWo cells.

4. The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro.

5. Isolation of hormone-producing clonal lines of human choriocarcinoma.

6. Development and characterization of established cell lines from primary and metastatic regions of human endometrial adenocarcinoma.

7. The establishment of human choriocarcinoma cell line in vitro.

8. Establishment and characterization of three new human gestational choriocarcinoma cell lines.

9. Establishment and characterization of a new human functional cell line from a choriocarcinoma.

10. Establishment and properties of a human choriocarcinoma cell line of ovarian origin.

1. Anticancer drug sensitivity testing using an oxygen electrode apparatus.

2. Heterogeneity of anticancer drug sensitivity in squamous cell carcinoma of the tongue.