Literature DB >> 15368579

Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.

Ralph Paulini1, Christian Lerner, Roland Jakob-Roetne, Gerhard Zürcher, Edilio Borroni, François Diederich.   

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Year:  2004        PMID: 15368579     DOI: 10.1002/cbic.200400084

Source DB:  PubMed          Journal:  Chembiochem        ISSN: 1439-4227            Impact factor:   3.164


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  6 in total

1.  Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.

Authors:  Andreas Link; Philipp Heidler; Marcel Kaiser; Reto Brun
Journal:  Mol Divers       Date:  2009-05-30       Impact factor: 2.943

Review 2.  Targeting Metalloenzymes for Therapeutic Intervention.

Authors:  Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal:  Chem Rev       Date:  2018-09-07       Impact factor: 60.622

Review 3.  Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders.

Authors:  Zhiguo Ma; Hongming Liu; Baojian Wu
Journal:  Br J Clin Pharmacol       Date:  2014-03       Impact factor: 4.335

Review 4.  SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.

Authors:  Jing Zhang; Yujun George Zheng
Journal:  ACS Chem Biol       Date:  2015-11-16       Impact factor: 5.100

5.  Mapping the conformational space accessible to catechol-O-methyltransferase.

Authors:  Andreas Ehler; Jörg Benz; Daniel Schlatter; Markus G Rudolph
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-07-25

6.  Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies.

Authors:  Pedro Cruz-Vicente; Ana M Gonçalves; Octávio Ferreira; João A Queiroz; Samuel Silvestre; Luís A Passarinha; Eugenia Gallardo
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-31
  6 in total

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