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Literature DB >> 15368395

Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase.

Samy Al-Rawi¹, Stephan Hinderlich, Werner Reutter, Athanassios Giannis.

Abstract

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Year: 2004 PMID： 15368395 DOI： 10.1002/anie.200453863

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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8 in total

1. Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents.

Authors: Yong Xu; Benjamin Brenning; Adrianne Clifford; David Vollmer; Jared Bearss; Carissa Jones; Virgil McCarthy; Chongtie Shi; Bradley Wolfe; Bhasker Aavula; Steve Warner; David J Bearss; Michael V McCullar; Raymond Schuch; Adam Pelzek; Shyam S Bhaskaran; C Erec Stebbins; Allan R Goldberg; Vincent A Fischetti; Hariprasad Vankayalapati
Journal: ACS Med Chem Lett Date: 2013-12-12 Impact factor: 4.345

2. Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.

Authors: Jacobo Martinez; Long Duc Nguyen; Stephan Hinderlich; Reinhold Zimmer; Eva Tauberger; Werner Reutter; Wolfram Saenger; Hua Fan; Sébastien Moniot
Journal: J Biol Chem Date: 2012-02-16 Impact factor: 5.157

3. A novel approach to decrease sialic acid expression in cells by a C-3-modified N-acetylmannosamine.

Authors: Paul R Wratil; Stephan Rigol; Barbara Solecka; Guido Kohla; Christoph Kannicht; Werner Reutter; Athanassios Giannis; Long D Nguyen
Journal: J Biol Chem Date: 2014-10-02 Impact factor: 5.157

Review 4. UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.

Authors: Stephan Hinderlich; Wenke Weidemann; Tal Yardeni; Rüdiger Horstkorte; Marjan Huizing
Journal: Top Curr Chem Date: 2015

5. Non-specific accumulation of glycosphingolipids in GNE myopathy.

Authors: Katherine A Patzel; Tal Yardeni; Erell Le Poëc-Celic; Petcharat Leoyklang; Heidi Dorward; Dominic S Alonzi; Nikolay V Kukushkin; Bixue Xu; Yongmin Zhang; Matthieu Sollogoub; Yves Blériot; William A Gahl; Marjan Huizing; Terry D Butters
Journal: J Inherit Metab Dis Date: 2013-10-18 Impact factor: 4.982

Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase.

1. Discovery of Novel Putative Inhibitors of UDP-GlcNAc 2-Epimerase as Potent Antibacterial Agents.

2. Crystal structures of N-acetylmannosamine kinase provide insights into enzyme activity and inhibition.

3. A novel approach to decrease sialic acid expression in cells by a C-3-modified N-acetylmannosamine.

Review 4. UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.

5. Non-specific accumulation of glycosphingolipids in GNE myopathy.

Review 6. Synthetic applications of chiral unsaturated epoxy alcohols prepared by sharpless asymmetric epoxidation.

7. Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs.

Review 8. Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design.