BACKGROUND: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. OBJECTIVE: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. DESIGN:Participants (n=53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (alpha)- and gamma (gamma)-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F(2t)-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. RESULTS: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in alpha-tocopherol and a marginally significant 4.9% increase (P=0.07) in isoprostane levels when women consumed 30 g alcohol/day (P=0.06 and 0.05 for overall effect of alcohol on alpha-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. CONCLUSIONS: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.
RCT Entities:
BACKGROUND: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. OBJECTIVE: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. DESIGN:Participants (n=53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (alpha)- and gamma (gamma)-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F(2t)-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. RESULTS: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in alpha-tocopherol and a marginally significant 4.9% increase (P=0.07) in isoprostane levels when women consumed 30 g alcohol/day (P=0.06 and 0.05 for overall effect of alcohol on alpha-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. CONCLUSIONS: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women.
Authors: Hui-Chen Wu; Laura A Brennan; Mandy Goldberg; Wendy K Chung; Ying Wei; Regina M Santella; Mary Beth Terry Journal: Free Radic Res Date: 2020-09-10
Authors: Terryl J Hartman; Julia S Sisti; Susan E Hankinson; Xia Xu; A Heather Eliassen; Regina Ziegler Journal: Horm Cancer Date: 2016-01-04 Impact factor: 3.869
Authors: Katie M Lebold; Kathleen A Grant; Willard M Freeman; Kristine M Wiren; Galen W Miller; Caitlin Kiley; Scott W Leonard; Maret G Traber Journal: Alcohol Clin Exp Res Date: 2010-11-30 Impact factor: 3.455
Authors: Edward Acheampong; Zahida Parveen; Aschalew Mengistu; Noel Ngoubilly; Brian Wigdahl; Albert S Lossinsky; Roger J Pomerantz; Muhammad Mukhtar Journal: J Virol Date: 2006-11-15 Impact factor: 5.103
Authors: MaryFran Sowers; Daniel McConnell; Mary L Jannausch; John F Randolph; Robert Brook; Ellen B Gold; Sybil Crawford; Bill Lasley Journal: Clin Endocrinol (Oxf) Date: 2007-11-02 Impact factor: 3.478
Authors: Jing Shen; Marilie D Gammon; Mary Beth Terry; Qiao Wang; Patrick Bradshaw; Susan L Teitelbaum; Alfred I Neugut; Regina M Santella Journal: Int J Cancer Date: 2009-04-01 Impact factor: 7.396
Authors: Kenneth J Mukamal; Catherine M Clowry; Margaret M Murray; Henk F J Hendriks; Eric B Rimm; Kaycee M Sink; Clement A Adebamowo; Lars O Dragsted; P Scott Lapinski; Mariana Lazo; John H Krystal Journal: Alcohol Clin Exp Res Date: 2016-09-30 Impact factor: 3.455
Authors: Joanne F Dorgan; Seungyoun Jung; Cher M Dallal; Min Zhan; Christina A Stennett; Yuji Zhang; Richard L Eckert; Linda G Snetselaar; Linda Van Horn Journal: Cancer Causes Control Date: 2019-12-11 Impact factor: 2.506