OBJECTIVES: It is often difficult to differentiate benign from malignant intraductal papillary mucinous tumors (IPMTs). This study aimed to differentiate them using various imaging techniques. METHODS: Receiver operating characteristic curves were used to establish optimal cutoff values to differentiate benign from malignant tumors in 121 patients with histologically confirmed IPMTs. RESULTS: For branch duct type, accuracy for malignancy was highest using endoscopic ultrasonography (EUS) to measure the cyst diameter, and accuracy was 68.2% at a cutoff value of 33.9 mm. For main duct type, accuracy was highest, 71.1% at a cutoff value of 8.4 mm for main duct diameter, with magnetic resonance cholangiopancreatography. For all imaging techniques and findings, accuracy was highest using EUS, 76.4% at a cutoff value of 5.4 mm for height of protrusion. Each imaging technique had a positive predictive value of 80% if the cut off value for the height of the protruding lesion was met. CONCLUSIONS: Malignancy can be strongly suspected when the height of protrusion exceeds the respective cutoff values. EUS was most effective to differentiate benign IPMTs from malignant tumors by assessing the height of protrusion.
OBJECTIVES: It is often difficult to differentiate benign from malignant intraductal papillary mucinous tumors (IPMTs). This study aimed to differentiate them using various imaging techniques. METHODS: Receiver operating characteristic curves were used to establish optimal cutoff values to differentiate benign from malignant tumors in 121 patients with histologically confirmed IPMTs. RESULTS: For branch duct type, accuracy for malignancy was highest using endoscopic ultrasonography (EUS) to measure the cyst diameter, and accuracy was 68.2% at a cutoff value of 33.9 mm. For main duct type, accuracy was highest, 71.1% at a cutoff value of 8.4 mm for main duct diameter, with magnetic resonance cholangiopancreatography. For all imaging techniques and findings, accuracy was highest using EUS, 76.4% at a cutoff value of 5.4 mm for height of protrusion. Each imaging technique had a positive predictive value of 80% if the cut off value for the height of the protruding lesion was met. CONCLUSIONS:Malignancy can be strongly suspected when the height of protrusion exceeds the respective cutoff values. EUS was most effective to differentiate benign IPMTs from malignant tumors by assessing the height of protrusion.
Authors: Seung Yup Lee; William R Lloyd; Malavika Chandra; Robert H Wilson; Barbara McKenna; Diane Simeone; James Scheiman; Mary-Ann Mycek Journal: Biomed Opt Express Date: 2013-11-14 Impact factor: 3.732
Authors: Muriel Genevay; Mari Mino-Kenudson; Kurt Yaeger; Ioannis T Konstantinidis; Cristina R Ferrone; Sarah Thayer; Carlos Fernandez-del Castillo; Dushyant Sahani; Brenna Bounds; David Forcione; William R Brugge; Martha Bishop Pitman Journal: Ann Surg Date: 2011-12 Impact factor: 12.969
Authors: Lawrence Mj Best; Vishal Rawji; Stephen P Pereira; Brian R Davidson; Kurinchi Selvan Gurusamy Journal: Cochrane Database Syst Rev Date: 2017-04-17
Authors: Molly M Cone; Jennifer D Rea; Brian S Diggs; Kevin G Billingsley; Brett C Sheppard Journal: HPB (Oxford) Date: 2010-12-22 Impact factor: 3.647
Authors: Jin-Young Choi; Jeong Min Lee; Min Woo Lee; Soo Jin Kim; Sun Young Choi; Ji Yang Kim; Joon Koo Han; Byung Ihn Choi Journal: Eur Radiol Date: 2009-04-18 Impact factor: 5.315
Authors: Dae Young Jun; Hyung Jun Kwon; Sang Geol Kim; Sung Hi Kim; Jae Min Chun; Young Bong Kwon; Kyung Jin Yoon; Yoon Jin Hwang; Young Kook Yun Journal: Korean J Hepatobiliary Pancreat Surg Date: 2011-12-15