J G Ray1, M J Vermeulen, C Meier, P R Wyatt. 1. Department of Medicine, Inner City Health Research Unit, St Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. rayj@smh.toronto.on.ca
Abstract
BACKGROUND: Most studies comparing women with and without pregestational diabetes mellitus have not systematically screened for fetal anomalies in early pregnancy, potentially leading to selection bias. AIM: To evaluate the risk for certain congenital anomalies in women participating in an antenatal maternal screening program. DESIGN: Retrospective cohort study. METHODS: We studied all women who underwent antenatal maternal serum screening in Ontario from 1994 to 2000. Fetal anomalies were documented antenatally by ultrasonography or at autopsy, and postnatally diagnosed birth defects were recorded after 20 weeks gestational age for all live- and stillborn affected infants. We compared the risk of open neural tube defects and urinary tract defects among women with and without pregestational diabetes. RESULTS: Of 413,219 women screened during pregnancy, 2069 (0.5%) had diabetes. Compared to non-diabetic women, the adjusted odds ratios (95%CI) for neural tube and urinary tract defects among women with diabetes were 2.5 (0.9-6.8) and 2.6 (1.4-4.9), respectively. DISCUSSION: Among women who undergo second trimester maternal serum screening, pregestational diabetes is associated with an increased risk of having a fetus with an open neural tube defect or urinary tract disorder.
BACKGROUND: Most studies comparing women with and without pregestational diabetes mellitus have not systematically screened for fetal anomalies in early pregnancy, potentially leading to selection bias. AIM: To evaluate the risk for certain congenital anomalies in women participating in an antenatal maternal screening program. DESIGN: Retrospective cohort study. METHODS: We studied all women who underwent antenatal maternal serum screening in Ontario from 1994 to 2000. Fetal anomalies were documented antenatally by ultrasonography or at autopsy, and postnatally diagnosed birth defects were recorded after 20 weeks gestational age for all live- and stillborn affected infants. We compared the risk of open neural tube defects and urinary tract defects among women with and without pregestational diabetes. RESULTS: Of 413,219 women screened during pregnancy, 2069 (0.5%) had diabetes. Compared to non-diabeticwomen, the adjusted odds ratios (95%CI) for neural tube and urinary tract defects among women with diabetes were 2.5 (0.9-6.8) and 2.6 (1.4-4.9), respectively. DISCUSSION: Among women who undergo second trimester maternal serum screening, pregestational diabetes is associated with an increased risk of having a fetus with an open neural tube defect or urinary tract disorder.
Authors: Mustafa A M Salih; Waleed R Murshid; Ashry Gad Mohamed; Lena C Ignacio; Julie E de Jesus; Rubana Baabbad; Hassan M El Bushra Journal: Sudan J Paediatr Date: 2014
Authors: Sohni Dean; Igor Rudan; Fernando Althabe; Aimee Webb Girard; Christopher Howson; Ana Langer; Joy Lawn; Mary-Elizabeth Reeve; Katherine C Teela; Mireille Toledano; Chandra-Mouli Venkatraman; José M Belizan; Josip Car; Kit Yee Chan; Subidita Chatterjee; Stanley Chitekwe; Tanya Doherty; France Donnay; Majid Ezzati; Khadija Humayun; Brian Jack; Zohra S Lassi; Reynaldo Martorell; Ysbrand Poortman; Zulfiqar A Bhutta Journal: PLoS Med Date: 2013-09-03 Impact factor: 11.069