Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Identification of basal promoter and enhancer elements in an untranslated region of the TT virus genome.

Literature DB >> 15367649

Identification of basal promoter and enhancer elements in an untranslated region of the TT virus genome.

Tetsuro Suzuki¹, Ryosuke Suzuki, Jin Li, Minako Hijikata, Mami Matsuda, Tiang-Cheng Li, Yoshiharu Matsuura, Shunji Mishiro, Tatsuo Miyamura.

Abstract

The regulation of TT virus (TTV) gene expression was characterized. Transient-transfection assays using reporter constructs revealed that a 113-nucleotide (nt) sequence within the untranslated region, proximal to the transcription initiation site and containing a TATA box motif, has a basal promoter activity. This sequence is well conserved among different TTV genotypes. Upstream stimulating factor bound to a consensus binding motif within this region and positively regulates TTV transcription. Furthermore, a 488-nt region upstream of the basal promoter exhibited enhancer activity, presumably in a cell type-specific manner. This study illustrates some of the mechanisms involved in the transcriptional regulation of TTV.

Entities: Chemical Species

Mesh：

Substances：

Year: 2004 PMID： 15367649 PMCID： PMC516427 DOI： 10.1128/JVI.78.19.10820-10824.2004

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

19 in total

1. Archaic structure of the gene encoding transcription factor USF.

Authors: Q Lin; X Luo; M Sawadogo
Journal: J Biol Chem Date: 1994-09-30 Impact factor: 5.157

2. A natural classification of the basic helix-loop-helix class of transcription factors.

Authors: W R Atchley; W M Fitch
Journal: Proc Natl Acad Sci U S A Date: 1997-05-13 Impact factor: 11.205

3. Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.

Authors: Takeya Tsutsumi; Tetsuro Suzuki; Takashi Shimoike; Ryosuke Suzuki; Kyoji Moriya; Yoshizumi Shintani; Hajime Fujie; Yoshiharu Matsuura; Kazuhiko Koike; Tatsuo Miyamura
Journal: Hepatology Date: 2002-04 Impact factor: 17.425

4. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

Authors: P D Gregor; M Sawadogo; R G Roeder
Journal: Genes Dev Date: 1990-10 Impact factor: 11.361

Review 5. TTV, a new human virus with single stranded circular DNA genome.

Authors: Shigeo Hino
Journal: Rev Med Virol Date: 2002 May-Jun Impact factor: 6.989

6. Full or near full length nucleotide sequences of TT virus variants (Types SANBAN and YONBAN) and the TT virus-like mini virus.

Authors: K Takahashi; M Hijikata; E I Samokhvalov; S Mishiro
Journal: Intervirology Date: 2000 Impact factor: 1.763

7. TT virus mRNAs detected in the bone marrow cells from an infected individual.

Authors: H Okamoto; T Nishizawa; A Tawara; M Takahashi; J Kishimoto; T Sai; Y Sugai
Journal: Biochem Biophys Res Commun Date: 2000-12-20 Impact factor: 3.575

8. Loss of USF transcriptional activity in breast cancer cell lines.

Authors: P M Ismail; T Lu; M Sawadogo
Journal: Oncogene Date: 1999-09-30 Impact factor: 9.867

9. Production and release of infectious hepatitis C virus from human liver cell cultures in the three-dimensional radial-flow bioreactor.

Authors: Hideki Aizaki; Seishi Nagamori; Mami Matsuda; Hayato Kawakami; Osamu Hashimoto; Hiroaki Ishiko; Masaaki Kawada; Tomokazu Matsuura; Satoshi Hasumura; Yoshiharu Matsuura; Tetsuro Suzuki; Tatsuo Miyamura
Journal: Virology Date: 2003-09-15 Impact factor: 3.616