| Literature DB >> 1536759 |
S Akimoto1, H Hayashi, H Ishikawa.
Abstract
The disaccharides constituting chondroitinase-digestible glycosaminoglycan (GAG) in the skin lesions of patients with systemic sclerosis were determined using high-performance liquid chromatography (HPLC). In scleroderma there was an increase in the amount of delta Di-4S(DS), the main disaccharide unit of dermatan sulphate, and a decrease in delta Di-HA, the disaccharide unit of hyaluronic acid, as compared with normal skin from a similar site. The distribution pattern of the main disaccharides constituting chondroitin sulphate and dermatan sulphate in scleroderma differed from that in scars or scleredema.Entities:
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Year: 1992 PMID: 1536759 DOI: 10.1111/j.1365-2133.1992.tb08399.x
Source DB: PubMed Journal: Br J Dermatol ISSN: 0007-0963 Impact factor: 9.302