Literature DB >> 15365258

Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.

Soon Young Shin1, Chang Gun Kim, Dong Dae Hong, Jung-Hye Kim, Young Han Lee.   

Abstract

The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many types of tumor tissues. Trifluoperazine (TFP), a phenothiazine class of antipsychotics, restored serum-induced Egr-1 expression in several cancer cell lines. We investigated the effect of Egr-1 expression on the TFP-induced inhibition of cell growth. Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and downregulated cyclin D1 level in U87MG glioma cells. Our results suggest that antipsychotics TFP exhibits antiproliferative activity through up-regulation of Egr-1.

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Year:  2004        PMID： 15365258     DOI： 10.1038/emm.2004.50

Source DB:  PubMed          Journal:  Exp Mol Med        ISSN： 1226-3613            Impact factor:   8.718


  6 in total

1.  High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase.

Authors:  Hideki Arimochi; Kyoji Morita
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

2.  Chlorpromazine activates p21Waf1/Cip1 gene transcription via early growth response-1 (Egr-1) in C6 glioma cells.

Authors:  Soon Young Shin; Chang Gun Kim; Se Hyun Kim; Yong Sik Kim; Yoongho Lim; Young Han Lee
Journal:  Exp Mol Med       Date:  2010-05-31       Impact factor: 8.718

Review 3.  Monoamines in glioblastoma: complex biology with therapeutic potential.

Authors:  Seamus Patrick Caragher; Robert Raymond Hall; Riasat Ahsan; Atique U Ahmed
Journal:  Neuro Oncol       Date:  2018-07-05       Impact factor: 12.300

4.  cAMP regulates vegetative growth and cell cycle in Candida albicans.

Authors:  Ajay Singh; Sadhna Sharma; Gopal K Khuller
Journal:  Mol Cell Biochem       Date:  2007-06-08       Impact factor: 3.396

5.  Sustained conditional knockdown reveals intracellular bone sialoprotein as essential for breast cancer skeletal metastasis.

Authors:  Marineta Kovacheva; Michael Zepp; Stefan M Berger; Martin R Berger
Journal:  Oncotarget       Date:  2014-07-30

6.  The antipsychotic agent trifluoperazine hydrochloride suppresses triple-negative breast cancer tumor growth and brain metastasis by inducing G0/G1 arrest and apoptosis.

Authors:  Zhanzhan Feng; Yong Xia; Tiantao Gao; Fuyan Xu; Qian Lei; Cuiting Peng; Yufei Yang; Qiang Xue; Xi Hu; Qianqian Wang; Ranran Wang; Zhiqiang Ran; Zhilin Zeng; Nan Yang; Zixin Xie; Luoting Yu
Journal:  Cell Death Dis       Date:  2018-09-26       Impact factor: 8.469
  6 in total

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