BACKGROUND: There is evidence for activation of the hypothalamus-pituitary-adrenal system in depressed patients to be associated with increased secretion of adrenal androgens. However, there is only limited information about the effect of different classes of antidepressants on the course of adrenal androgens. METHODS: Dehydroepiandrosterone sulfate (DHEA-S) serum concentrations were measured in 80 patients being treated with amitriptyline (AMI) or paroxetine (PAROX) for a period of 35 days. RESULTS: Using analysis of variance with repeated measures, we found a significant effect of treatment upon DHEA-S serum concentrations that declined more in AMI-treated (before vs. after: 1.89+/-1.16 vs. 1.46 +/- 0.96 mg/l), compared to PAROX-treated patients (1.56+/-1.09 vs. 1.50+/-1.04 mg/l). CONCLUSIONS: Our results show changes in DHEA-S serum concentrations during antidepressant treatment to depend on medication.
BACKGROUND: There is evidence for activation of the hypothalamus-pituitary-adrenal system in depressedpatients to be associated with increased secretion of adrenal androgens. However, there is only limited information about the effect of different classes of antidepressants on the course of adrenal androgens. METHODS:Dehydroepiandrosterone sulfate (DHEA-S) serum concentrations were measured in 80 patients being treated with amitriptyline (AMI) or paroxetine (PAROX) for a period of 35 days. RESULTS: Using analysis of variance with repeated measures, we found a significant effect of treatment upon DHEA-S serum concentrations that declined more in AMI-treated (before vs. after: 1.89+/-1.16 vs. 1.46 +/- 0.96 mg/l), compared to PAROX-treated patients (1.56+/-1.09 vs. 1.50+/-1.04 mg/l). CONCLUSIONS: Our results show changes in DHEA-S serum concentrations during antidepressant treatment to depend on medication.
Authors: Christina M Hough; Daniel Lindqvist; Elissa S Epel; Molly St Denis; Victor I Reus; F Saverio Bersani; Rebecca Rosser; Laura Mahan; Heather M Burke; Owen M Wolkowitz; Synthia H Mellon Journal: Psychoneuroendocrinology Date: 2016-12-05 Impact factor: 4.905
Authors: Erin M MacKenzie; John Odontiadis; Jean-Michel Le Mellédo; Trevor I Prior; Glen B I Baker Journal: Cell Mol Neurobiol Date: 2007-08 Impact factor: 5.046
Authors: Elizabeth E Van Voorhees; Michelle F Dennis; F Joseph McClernon; Patrick S Calhoun; Natalie A Buse; Jean C Beckham Journal: J Clin Psychopharmacol Date: 2013-08 Impact factor: 3.153