Literature DB >> 15365027

Potential screening assay for undetectable viruses on the basis of their capacity to induce alpha interferon production.

Barbara Schmidt1, Brittany Ashlock, Frank Neipel, Jay A Levy.   

Abstract

High interferon production by plasmacytoid dendritic cells (PDC) was unexpectedly noted after their coculture with CD4(+) cells from a healthy donor whose cells subsequently showed human herpesvirus type 6 and 7 infections. This release of interferon was not observed with uninfected normal CD4(+) cells. Induction of PDC interferon production could help screen for covert virus infections.

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Year:  2004        PMID： 15365027      PMCID： PMC516323          DOI： 10.1128/JCM.42.9.4300-4302.2004

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  6 in total

1.  Activation-induced CD4+ T cell death in HIV-positive individuals correlates with Fas susceptibility, CD4+ T cell count, and HIV plasma viral copy number.

Authors:  D H Dockrell; A D Badley; A Algeciras-Schimnich; M Simpson; R Schut; D H Lynch; C V Paya
Journal:  AIDS Res Hum Retroviruses       Date:  1999-11-20       Impact factor: 2.205

2.  CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

Authors:  C E Mackewicz; H W Ortega; J A Levy
Journal:  J Clin Invest       Date:  1991-04       Impact factor: 14.808

3.  Interferon induction by human herpesvirus 6 in human mononuclear cells.

Authors:  H Kikuta; A Nakane; H Lu; Y Taguchi; T Minagawa; S Matsumoto
Journal:  J Infect Dis       Date:  1990-07       Impact factor: 5.226

4.  Optimal conditions for recovery of the human immunodeficiency virus from peripheral blood mononuclear cells.

Authors:  B A Castro; C D Weiss; L D Wiviott; J A Levy
Journal:  J Clin Microbiol       Date:  1988-11       Impact factor: 5.948

5.  In vitro activation of human herpesviruses 6 and 7 from latency.

Authors:  G C Katsafanas; E C Schirmer; L S Wyatt; N Frenkel
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

6.  Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population.

Authors:  J A Levy; F Ferro; D Greenspan; E T Lennette
Journal:  Lancet       Date:  1990-05-05       Impact factor: 79.321
  6 in total

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