Literature DB >> 15364034

Flanking gene and genetic background problems in genetically manipulated mice.

Wim E Crusio1.   

Abstract

Mice carrying engineered genetic modifications have become an indispensable tool in the study of gene functioning. The interpretation of results obtained with targeted mutants is not completely straightforward, however, because of genetic complications due to linkage and epistasis. Effects of closely linked genes flanking the targeted locus might sometimes be responsible for phenotypic changes ascribed to the null mutation. The effects of the latter might also be modified by the general genetic background. This review presents some examples and discusses some simple strategies to deal with these complications.

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Year:  2004        PMID： 15364034     DOI： 10.1016/j.biopsych.2003.12.026

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  50 in total

1.  Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene.

Authors:  Amy F Eisener-Dorman; David A Lawrence; Valerie J Bolivar
Journal:  Brain Behav Immun       Date:  2010-05-23       Impact factor: 7.217

Review 2.  The relevance of individual genetic background and its role in animal models of epilepsy.

Authors:  P Elyse Schauwecker
Journal:  Epilepsy Res       Date:  2011-10-15       Impact factor: 3.045

Review 3.  Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface.

Authors:  John L Waddington; Colm O'Tuathaigh; Gerard O'Sullivan; Katsunori Tomiyama; Noriaki Koshikawa; David T Croke
Journal:  Psychopharmacology (Berl)       Date:  2005-09-29       Impact factor: 4.530

4.  Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtype.

Authors:  Natalie K Bainbridge; Lisa R Koselke; Jongrye Jeon; Kathleen R Bailey; Jürgen Wess; Jacqueline N Crawley; Craige C Wrenn
Journal:  Behav Brain Res       Date:  2008-02-08       Impact factor: 3.332

5.  Scent marking behavior in male C57BL/6J mice: sexual and developmental determination.

Authors:  Hiroyuki Arakawa; Keiko Arakawa; D Caroline Blanchard; Robert J Blanchard
Journal:  Behav Brain Res       Date:  2007-05-22       Impact factor: 3.332

6.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells.

Authors:  Rohit N Kulkarni
Journal:  Endocrinology       Date:  2009-07       Impact factor: 4.736

Review 7.  Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds.

Authors:  Jennifer A Wilking; Jerry A Stitzel
Journal:  Neuropharmacology       Date:  2014-12-09       Impact factor: 5.250

8.  Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression.

Authors:  Fiona C Mansergh; Timothy Wells; Carole Elford; Samuel L Evans; Mark J Perry; Martin J Evans; Bronwen A J Evans
Journal:  Physiol Genomics       Date:  2007-09-18       Impact factor: 3.107

9.  Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder.

Authors:  Timothy M DeLorey; Peyman Sahbaie; Ezzat Hashemi; Gregg E Homanics; J David Clark
Journal:  Behav Brain Res       Date:  2007-09-14       Impact factor: 3.332

Review 10.  Cautionary insights on knockout mouse studies: the gene or not the gene?

Authors:  Amy F Eisener-Dorman; David A Lawrence; Valerie J Bolivar
Journal:  Brain Behav Immun       Date:  2008-09-12       Impact factor: 7.217
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