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Literature DB >> 15363437

The changing landscape of antiparasitic drug discovery for veterinary medicine.

Timothy G Geary, George A Conder, Bernard Bishop.

Abstract

Changes in economic imperatives in the pharmaceutical industry have led to a wave of consolidation, which has had the unintended side effect of shrinking the resource devoted to antiparasitic drug discovery in animal health companies. Scientific changes have altered the way in which drugs could be discovered in the future. New science and business models will need to be implemented to address the demand for innovative antiparasitic drugs in veterinary medicine. Novel drugs are needed to combat drug resistance and for currently non-addressed problems. At the center of the future for this field, however, lies the need for more support into the basic research on the biology of parasites.

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Year: 2004 PMID： 15363437 DOI： 10.1016/j.pt.2004.08.003

Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922

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Cited

13 in total

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Authors: S R Purdy; L F Gagliardo; S Lefman; P J S Hamel; S Ku; T Mainini; G Hoyt; K Justus; L P Daley-Bauer; M S Duffy; J A Appleton
Journal: Clin Vaccine Immunol Date: 2012-05-16

Review 2. Control of nematode parasites with agents acting on neuro-musculature systems: lessons for neuropeptide ligand discovery.

Authors: Richard J Martin; Alan P Robertson
Journal: Adv Exp Med Biol Date: 2010 Impact factor: 2.622

3. The nematode neuropeptide, AF2 (KHEYLRF-NH2), increases voltage-activated calcium currents in Ascaris suum muscle.

Authors: S Verma; A P Robertson; R J Martin
Journal: Br J Pharmacol Date: 2007-05-21 Impact factor: 8.739

Review 4. The challenges of developing novel antiparasitic drugs.

Authors: Debra J Woods; Tracey M Williams
Journal: Invert Neurosci Date: 2007-11-15

5. Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.

Authors: Puranik Purushottamachar; Abhijit M Godbole; Lalji K Gediya; Marlena S Martin; Tadas S Vasaitis; Andrew K Kwegyir-Afful; Senthilmurugan Ramalingam; Zeynep Ates-Alagoz; Vincent C O Njar
Journal: J Med Chem Date: 2013-06-07 Impact factor: 7.446

6. Experimental infection of Haemonchus contortus strains resistant and susceptible to benzimidazoles and the effect on mast cells distribution in the stomach of Mongolian gerbils (Meriones unguiculatus).

Authors: Alzbeta Königová; Gabriela Hrckova; Samuel Velebný; Július Corba; Marián Várady
Journal: Parasitol Res Date: 2007-11-27 Impact factor: 2.289

The changing landscape of antiparasitic drug discovery for veterinary medicine.

1. Analysis of heavy-chain antibody responses and resistance to Parelaphostrongylus tenuis in experimentally infected alpacas.

Review 2. Control of nematode parasites with agents acting on neuro-musculature systems: lessons for neuropeptide ligand discovery.

3. The nematode neuropeptide, AF2 (KHEYLRF-NH2), increases voltage-activated calcium currents in Ascaris suum muscle.

Review 4. The challenges of developing novel antiparasitic drugs.

5. Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.

6. Experimental infection of Haemonchus contortus strains resistant and susceptible to benzimidazoles and the effect on mast cells distribution in the stomach of Mongolian gerbils (Meriones unguiculatus).

Review 7. Parasite neuropeptide biology: Seeding rational drug target selection?

8. Functional expression of parasite drug targets and their human orthologs in yeast.

9. Sorption of selected antiparasitics in soils and sediments.

Review 10. The Biology and Ecology of Cat Fleas and Advancements in Their Pest Management: A Review.