Literature DB >> 15363403

Lipid phase perturbations and the unfolded protein response.

David Ron1, Seiichi Oyadomari.   

Abstract

Recent studies of the consequences of ganglioside accumulation in lysosomal storage disease and free cholesterol accumulation in cell membranes in atherosclerosis suggest an unexpected link between perturbation of the endoplasmic reticulum membrane's lipid phase, induction of the unfolded protein response, and cell death.

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Year:  2004        PMID： 15363403     DOI： 10.1016/j.devcel.2004.08.011

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


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