PURPOSE: To compare the lymphatic transport and the portal absorption of halofantrine (Hf) when administered in (i) a triacylglycerol (TG) solution, (ii) an o/w-emulsion that contains a metabolizable surfactant, and (iii) an o/w-emulsion that contains a synthetic surfactant. METHODS: Lymph cannulated rats were orally dosed with Hf in a TG solution or in o/w-emulsions dispersed by lecithin or Cremophor RH40. Lymph was continuously collected, and blood was sampled periodically in the course of 30 h. Hf in the lymph and blood and TG and phosphatidyl choline (PC) in the lymph were analyzed. RESULTS: A significantly (p < 0.05) higher level of Hf was found in the intestinal lymph when dosed in one of the emulsions (22.8+/-2.8% and 20.2+/-2.5%) compared to in the TG solution (7.9+/-1.1%). No difference in the lymphatic transport of Hf was observed between the two emulsions. The portal absorption of Hf was similar for the three vehicles. CONCLUSIONS: The emulsified vehicles favor an increased lymphatic transport of Hf. The portal transport of Hf was not significantly different for the three vehicles. This indicates that a different degree of dispersion of the TG vehicle can change the route of transportation of Hf.
PURPOSE: To compare the lymphatic transport and the portal absorption of halofantrine (Hf) when administered in (i) a triacylglycerol (TG) solution, (ii) an o/w-emulsion that contains a metabolizable surfactant, and (iii) an o/w-emulsion that contains a synthetic surfactant. METHODS: Lymph cannulated rats were orally dosed with Hf in a TG solution or in o/w-emulsions dispersed by lecithin or Cremophor RH40. Lymph was continuously collected, and blood was sampled periodically in the course of 30 h. Hf in the lymph and blood and TG and phosphatidyl choline (PC) in the lymph were analyzed. RESULTS: A significantly (p < 0.05) higher level of Hf was found in the intestinal lymph when dosed in one of the emulsions (22.8+/-2.8% and 20.2+/-2.5%) compared to in the TG solution (7.9+/-1.1%). No difference in the lymphatic transport of Hf was observed between the two emulsions. The portal absorption of Hf was similar for the three vehicles. CONCLUSIONS: The emulsified vehicles favor an increased lymphatic transport of Hf. The portal transport of Hf was not significantly different for the three vehicles. This indicates that a different degree of dispersion of the TG vehicle can change the route of transportation of Hf.
Authors: D M Woodcock; M E Linsenmeyer; G Chojnowski; A B Kriegler; V Nink; L K Webster; W H Sawyer Journal: Br J Cancer Date: 1992-07 Impact factor: 7.640
Authors: Natalie L Trevaskis; David M Shackleford; William N Charman; Glenn A Edwards; Anne Gardin; Silke Appel-Dingemanse; Olivier Kretz; Bruno Galli; Christopher J H Porter Journal: Pharm Res Date: 2009-03-12 Impact factor: 4.200
Authors: Zhenbao Li; Wenjuan Zhang; Yan Gao; Rongwu Xiang; Yan Liu; Mingming Hu; Mei Zhou; Xiaohong Liu; Yongjun Wang; Zhonggui He; Yinghua Sun; Jin Sun Journal: Drug Deliv Transl Res Date: 2017-02 Impact factor: 4.617