Literature DB >> 15359081

Forefront of Na+/Ca2+ exchanger studies: stoichiometry of cardiac Na+/Ca2+ exchanger; 3:1 or 4:1?

Masamitsu Hinata1, Junko Kimura.   

Abstract

The stoichiometry of the Na+/Ca2+ exchanger (NCX) had been generally accepted as 3 Na+:1 Ca2+. However, recently a challenging stoichiometry of 4:1 was proposed. Therefore, using guinea pig ventricular cells, we re-examined the stoichiometry by measuring the reversal potential of the NCX current and intracellular Ca2+ concentrations under the whole-cell voltage clamp. We confirmed that the stoichiometry of NCX is 3:1 not 4:1. In addition, we explored the possible reasons for obtaining erroneous results of a 4:1 stoichiometry.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15359081     DOI： 10.1254/jphs.fmj04002x3

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  11 in total

Review 1.  Na(+) entry and modulation of Na(+)/Ca(2+) exchange as a key mechanism of TRPC signaling.

Authors:  Petra Eder; Michael Poteser; Christoph Romanin; Klaus Groschner
Journal:  Pflugers Arch       Date:  2005-05-28       Impact factor: 3.657

2.  Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.

Authors:  Michael J Riedel; István Baczkó; Gavin J Searle; Nicola Webster; Matthew Fercho; Lynn Jones; Jessica Lang; Jonathan Lytton; Jason R B Dyck; Peter E Light
Journal:  EMBO J       Date:  2006-09-14       Impact factor: 11.598

3.  Simulated ischaemia induces Ca2+-independent glutamatergic vesicle release through actin filament depolymerization in area CA1 of the hippocampus.

Authors:  Adriana L Andrade; David J Rossi
Journal:  J Physiol       Date:  2010-03-08       Impact factor: 5.182

4.  Calcium-Dependent Regulation of Ion Channels.

Authors:  Vikas N Shah; Benjamin Chagot; Walter J Chazin
Journal:  Calcium Bind Proteins       Date:  2006 Oct-Dec

5.  Cardiac P2X purinergic receptors as a new pathway for increasing Na⁺ entry in cardiac myocytes.

Authors:  Jian-Bing Shen; Ronghua Yang; Achilles Pappano; Bruce T Liang
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-09-19       Impact factor: 4.733

6.  Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers.

Authors:  Diane E Roberts; Toshio Matsuda; Ratna Bose
Journal:  Br J Pharmacol       Date:  2012-02       Impact factor: 8.739

7.  Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation.

Authors:  Fabrizio Marinelli; Lior Almagor; Reuben Hiller; Moshe Giladi; Daniel Khananshvili; José D Faraldo-Gómez
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-02       Impact factor: 11.205

8.  Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblasts.

Authors:  Kazuho Sakamoto; Yuki Owada; Yayoi Shikama; Ikuo Wada; Satoshi Waguri; Takahiro Iwamoto; Junko Kimura
Journal:  J Physiol       Date:  2009-09-21       Impact factor: 5.182

9.  β-Adrenoceptor/PKA-stimulation, Na(+)-Ca(2+) exchange and PKA-activated Cl(-) currents in rabbit cardiomyocytes: a conundrum.

Authors:  Palash Barman; Stéphanie C M Choisy; Jules C Hancox; Andrew F James
Journal:  Cell Calcium       Date:  2011-03-25       Impact factor: 6.817

10.  Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1.

Authors:  Caglar Gök; Alice Main; Xing Gao; Zsombor Kerekes; Fiona Plain; Chien-Wen Kuo; Alan D Robertson; Niall J Fraser; William Fuller
Journal:  Cell Calcium       Date:  2021-04-08       Impact factor: 6.817
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.