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Literature DB >> 15358734

'Am not I a fly like thee?' From genes in fruit flies to behavior in humans.

Abstract

The fruit fly Drosophila melanogaster has provided insight into the role of genes in behavior, some of which have relevant implications for humans. Mutants induced or engineered in the laboratory have contributed to our understanding of biological rhythms, learning, memory, neurodegenerative disease and drug response. Studies of naturally occurring genetic variation in behavior have advanced our understanding of what kinds of variants arise spontaneously and contribute to behavior.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 15358734 DOI： 10.1093/hmg/ddh248

Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150

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Cited

16 in total

Review 1. The Drosophila melanogaster as Genetic Model System to Dissect the Mechanisms of Disease that Lead to Neurodegeneration in Adrenoleukodystrophy.

Authors: Margret H Bülow; Brendon D Parsons; Francesca Di Cara
Journal: Adv Exp Med Biol Date: 2020 Impact factor: 2.622

2. Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila.

Authors: Jose Agosto; James C Choi; Katherine M Parisky; Geoffrey Stilwell; Michael Rosbash; Leslie C Griffith
Journal: Nat Neurosci Date: 2008-01-27 Impact factor: 24.884

Review 3. Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.

Authors: Matthew D Rand
Journal: Neurotoxicol Teratol Date: 2009-06-24 Impact factor: 3.763

4. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila.

Authors: A B Pizzo; C S Karam; Y Zhang; H Yano; R J Freyberg; D S Karam; Z Freyberg; A Yamamoto; B D McCabe; J A Javitch
Journal: Mol Psychiatry Date: 2012-06-19 Impact factor: 15.992

5. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster.

Authors: Mirjam Appel; Claus-Jürgen Scholz; Tobias Müller; Marcus Dittrich; Christian König; Marie Bockstaller; Tuba Oguz; Afshin Khalili; Emmanuel Antwi-Adjei; Tamas Schauer; Carla Margulies; Hiromu Tanimoto; Ayse Yarali
Journal: PLoS One Date: 2015-05-18 Impact factor: 3.240

6. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.

Authors: Anna Sivachenko; Hannah B Gordon; Suzanne S Kimball; Erin J Gavin; Joshua L Bonkowsky; Anthea Letsou
Journal: Dis Model Mech Date: 2016-02-18 Impact factor: 5.758

'Am not I a fly like thee?' From genes in fruit flies to behavior in humans.

Review 1. The Drosophila melanogaster as Genetic Model System to Dissect the Mechanisms of Disease that Lead to Neurodegeneration in Adrenoleukodystrophy.

2. Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila.

Review 3. Drosophotoxicology: the growing potential for Drosophila in neurotoxicology.

4. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila.

5. Genome-Wide Association Analyses Point to Candidate Genes for Electric Shock Avoidance in Drosophila melanogaster.

6. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.

Review 7. The complex genetic basis of simple behavior.

8. A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions.

9. Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling.

Review 10. Mottled Mice and Non-Mammalian Models of Menkes Disease.