Literature DB >> 15358582

Functional roles of NKT cell in the immune system.

Ken-ichiro Seino1, Masaru Taniguchi.   

Abstract

CD1d-restricted Natural Killer T cells (NKT cells), a novel lymphocyte lineage, are considered to play an intermediary role bridging innate and acquired immunity. This review discusses the characteristics of NKT cells and their biological significance in the immune system, and summarizes their in vivo functions observed in a number of pathological settings, including infectious diseases, cancer, autoimmunity, and transplantation. Further, we discuss recent data that have generated considerable interest in utilizing NKT cells as targets of new therapeutic interventions in various human diseases.

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Year:  2004        PMID： 15358582     DOI： 10.2741/1418

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  14 in total

1.  Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells.

Authors:  Jakub Tolar; Matthew J O'shaughnessy; Angela Panoskaltsis-Mortari; Ron T McElmurry; Scott Bell; Megan Riddle; R Scott McIvor; Stephen R Yant; Mark A Kay; Diane Krause; Catherine M Verfaillie; Bruce R Blazar
Journal:  Blood       Date:  2006-01-12       Impact factor: 22.113

Review 2.  T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology.

Authors:  Gikas E Katsifis; Niki M Moutsopoulos; Sharon M Wahl
Journal:  Clin Rev Allergy Immunol       Date:  2007-06       Impact factor: 8.667

3.  Characterization of human invariant natural killer T cells expressing FoxP3.

Authors:  Péter Engelmann; Klára Farkas; János Kis; Geoffrey Richman; Zhaoyun Zhang; Chong Wee Liew; Maciej Borowiec; Monika A Niewczas; Heyam Jalahej; Tihamér Orbán
Journal:  Int Immunol       Date:  2011-06-27       Impact factor: 4.823

4.  Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

Authors:  Kazuko Azakami; Tomoo Sato; Natsumi Araya; Atae Utsunomiya; Ryuji Kubota; Kenshi Suzuki; Daisuke Hasegawa; Toshihiko Izumi; Hidetoshi Fujita; Satoko Aratani; Ryoji Fujii; Naoko Yagishita; Hajime Kamijuku; Takuro Kanekura; Ken-ichiro Seino; Kusuki Nishioka; Toshihiro Nakajima; Yoshihisa Yamano
Journal:  Blood       Date:  2009-08-07       Impact factor: 22.113

5.  Natural killer T cell and TLR9 agonists as mucosal adjuvants for sublingual vaccination with clade C HIV-1 envelope protein.

Authors:  Shailbala Singh; Guojun Yang; Siddappa N Byrareddy; Michael A Barry; K Jagannadha Sastry
Journal:  Vaccine       Date:  2014-11-02       Impact factor: 3.641

6.  Toll-like receptor 3 ligand dampens liver inflammation by stimulating Valpha 14 invariant natural killer T cells to negatively regulate gammadeltaT cells.

Authors:  Tommy R Gardner; Qingling Chen; Yijun Jin; Maureen N Ajuebor
Journal:  Am J Pathol       Date:  2010-02-18       Impact factor: 4.307

7.  Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.

Authors:  Edy Y Kim; John T Battaile; Anand C Patel; Yingjian You; Eugene Agapov; Mitchell H Grayson; Loralyn A Benoit; Derek E Byers; Yael Alevy; Jennifer Tucker; Suzanne Swanson; Rose Tidwell; Jeffrey W Tyner; Jeffrey D Morton; Mario Castro; Deepika Polineni; G Alexander Patterson; Reto A Schwendener; John D Allard; Gary Peltz; Michael J Holtzman
Journal:  Nat Med       Date:  2008-05-18       Impact factor: 53.440

Review 8.  Immune pathways for translating viral infection into chronic airway disease.

Authors:  Michael J Holtzman; Derek E Byers; Loralyn A Benoit; John T Battaile; Yingjian You; Eugene Agapov; Chaeho Park; Mitchell H Grayson; Edy Y Kim; Anand C Patel
Journal:  Adv Immunol       Date:  2009       Impact factor: 3.543

9.  Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells.

Authors:  Everett H Meyer; Sho Goya; Omid Akbari; Gerald J Berry; Paul B Savage; Mitchell Kronenberg; Toshinori Nakayama; Rosemarie H DeKruyff; Dale T Umetsu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-14       Impact factor: 11.205

10.  The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure.

Authors:  Isaac Downs; Jianfeng Liu; Tak Yee Aw; Patrick A Adegboyega; Maureen N Ajuebor
Journal:  PLoS One       Date:  2012-06-06       Impact factor: 3.240
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