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Literature DB >> 15358412

Cholesterol and the activity of bacterial toxins.

Abstract

Cholesterol may affect the activity of microbial toxins in a direct, specific way, or it may exert indirect effects because of its role in membrane fluidity, membrane line tension, and in the stabilization of rafts in the cytoplasmic membrane. The thiol-activated toxins of gram-positive bacteria, and the cytolysin of Vibrio cholerae are presented as examples of specific toxin-cholesterol interaction. Several mechanisms of indirect effects of cholesterol are discussed using examples such as Staphylococcus aureus alpha-hemolysin, aerolysin, and diphtheria toxin.

Entities: Chemical Species

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Year: 2004 PMID： 15358412 DOI： 10.1016/j.femsle.2004.07.059

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

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Cited

30 in total

1. Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore.

Authors: Harpreet Singh; Richard H Ashley
Journal: Biophys J Date: 2005-12-09 Impact factor: 4.033

2. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner.

Authors: Dhammika N Atapattu; Charles J Czuprynski
Journal: Infect Immun Date: 2007-08-06 Impact factor: 3.441

Review 10. Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

Authors: Gunnar N Schroeder; Hubert Hilbi
Journal: Clin Microbiol Rev Date: 2008-01 Impact factor: 26.132

Cholesterol and the activity of bacterial toxins.

1. Redox regulation of CLIC1 by cysteine residues associated with the putative channel pore.

2. Mannheimia haemolytica leukotoxin binds to lipid rafts in bovine lymphoblastoid cells and is internalized in a dynamin-2- and clathrin-dependent manner.

Review 3. Aegerolysins: structure, function, and putative biological role.

4. The aromatic ring of phenylalanine 334 is essential for oligomerization of Vibrio vulnificus hemolysin.

Review 5. Common structural features of cholesterol binding sites in crystallized soluble proteins.

6. Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains.

Review 7. Challenges and approaches to understand cholesterol-binding impact on membrane protein function: an NMR view.

Review 8. Aggregatibacter actinomycetemcomitans leukotoxin: From mechanism to targeted anti-toxin therapeutics.

9. Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.

Review 10. Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.