| Literature DB >> 15358330 |
Satish N Nadig1, Basker Periyasamy, Stephen F Shafizadeh, Carmen Polito, Ryan N Fiorini, David Rodwell, Zachary Evans, Gang Cheng, Dana Dunkelberger, Michael Schmidt, Sally E Self, Kenneth D Chavin.
Abstract
The number of patients requiring organ transplants still outpaces the number of available transplantable organs. During the process of orthotopic liver transplantation (OLTx), donor organs undergo significant stress resulting from ischemia and reperfusion. Healthy organs respond to this stressful environment with compensatory mechanisms that ideally allow for complete recovery. However, "marginal" organs do not compensate as well. Hepatic steatosis typically renders an organ nontransplantable; a liver with 30% or more fat has a 25% chance of primary nonfunction (PNF) or graft failure after a technically sound operation. In this study, we report on the significant markers of cellular ultrastructural change in steatotic livers. These include glycogen content, mitochondrial swelling, and hepatocellular blebbing. The data disclosed here argue that further investigation of these factors in marginal organs subjected to I/R may better facilitate our understanding of PNF.Entities:
Mesh：
Year: 2004 PMID： 15358330 DOI： 10.1016/j.gassur.2004.04.002
Source DB: PubMed Journal: J Gastrointest Surg ISSN： 1091-255X Impact factor: 3.452