Literature DB >> 1535830

A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8- alpha beta T cell receptor positive T cells.

Y Watanabe1, O Mazda, Y Aiba, K Iwai, J Gyotoku, S Ideyama, J Miyazaki, Y Katsura.   

Abstract

A fibroblastoid cell line TSt-4 was established from fetal thymus tissue of C57BL/6 mice. When fetal thymus (FT) cells or CD4-8- (DN) cells of adult thymuses were cultured on the monolayer of TSt-4, a considerable proportion of lymphocytes expressed CD4 or both CD4 and CD8 within 1 day, and the CD4+CD8- cells were maintained further while the CD4+8+ cells disappeared by Day 5. A large proportion of cells generated from DN cells but not FT cells was shown to express CD3 and T cell receptor alpha beta. Addition of recombinant interleukin (IL)-7 into the cultures resulted in a marked increase of cell recovery without virtual change in differentiation process of alpha beta lineage. The present work strongly suggests that thymic fibroblasts play an important role in T cell differentiation and IL-7 contributes to supporting proliferation of differentiated cells.

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Year:  1992        PMID： 1535830     DOI： 10.1016/0008-8749(92)90299-5

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  6 in total

1.  Enrichment of c-kit+ Lin- haemopoietic progenitor cells that commit themselves to extrathymic T cells in in vitro culture of appendix mononuclear cells.

Authors:  T Koya; S Honda; J Narita; H Watanabe; M Arakawa; T Abo
Journal:  Immunology       Date:  1999-03       Impact factor: 7.397

2.  Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.

Authors:  Kazuyo Moro; Taketo Yamada; Masanobu Tanabe; Tsutomu Takeuchi; Tomokatsu Ikawa; Hiroshi Kawamoto; Jun-Ichi Furusawa; Masashi Ohtani; Hideki Fujii; Shigeo Koyasu
Journal:  Nature       Date:  2009-12-20       Impact factor: 49.962

3.  Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization.

Authors:  Kazuhiro Suzuki; Ruowen Sun; Makoto Origuchi; Masahiko Kanehira; Takenori Takahata; Jugoh Itoh; Akihiro Umezawa; Hiroshi Kijima; Shinsaku Fukuda; Yasuo Saijo
Journal:  Mol Med       Date:  2011-03-11       Impact factor: 6.354

Review 4.  T-Cell Progenitors As A New Immunotherapy to Bypass Hurdles of Allogeneic Hematopoietic Stem Cell Transplantation.

Authors:  Pierre Gaudeaux; Ranjita Devi Moirangthem; Aurélie Bauquet; Laura Simons; Akshay Joshi; Marina Cavazzana; Olivier Nègre; Shabi Soheili; Isabelle André
Journal:  Front Immunol       Date:  2022-07-07       Impact factor: 8.786

5.  Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis.

Authors:  F Ushikubi; Y Aiba; K Nakamura; T Namba; M Hirata; O Mazda; Y Katsura; S Narumiya
Journal:  J Exp Med       Date:  1993-11-01       Impact factor: 14.307

6.  Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.

Authors:  Satoshi Koga; Katsuto Hozumi; Ken-Ichi Hirano; Masaki Yazawa; Tommy Terooatea; Aki Minoda; Takashi Nagasawa; Shigeo Koyasu; Kazuyo Moro
Journal:  J Exp Med       Date:  2018-05-04       Impact factor: 14.307
  6 in total

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