| Literature DB >> 15357997 |
Gary R W Pitt1, Andrzej R Batt, Robert M Haigh, Andrew M Penson, Peter A Robson, David P Rooker, André L Tartar, Julie E Trim, Christopher M Yea, Michael B Roe.
Abstract
A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).Entities:
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Year: 2004 PMID： 15357997 DOI： 10.1016/j.bmcl.2004.04.107
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823