Literature DB >> 15357992

Discovery of new chemical leads for prostaglandin D2 receptor antagonists.

Kazuhiko Torisu1, Kaoru Kobayashi, Maki Iwahashi, Hiromu Egashira, Yoshihiko Nakai, Yutaka Okada, Fumio Nanbu, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda.   

Abstract

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid 2 was discovered as a new chemical lead for a prostaglandin D2 (PGD2) receptor antagonist. Structure-activity relationship data are also presented.

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Year:  2004        PMID： 15357992     DOI： 10.1016/j.bmcl.2004.06.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep.

Authors:  Wei-Min Qu; Zhi-Li Huang; Xin-Hong Xu; Kosuke Aritake; Naomi Eguchi; Fumio Nambu; Shu Narumiya; Yoshihiro Urade; Osamu Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-08       Impact factor: 11.205

Review 2.  Prostanoid receptor antagonists: development strategies and therapeutic applications.

Authors:  R L Jones; M A Giembycz; D F Woodward
Journal:  Br J Pharmacol       Date:  2009-07-15       Impact factor: 8.739

3.  Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up.

Authors:  Andy J Liedtke; Kwangho Kim; Donald F Stec; Gary A Sulikowski; Lawrence J Marnett
Journal:  Tetrahedron       Date:  2012-12-02       Impact factor: 2.457
  3 in total

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