| Literature DB >> 15357988 |
K Shankaran1, Karla L Donnelly, Shrenik K Shah, Ravindra N Guthikonda, Malcolm MacCoss, John L Humes, Stephen G Pacholok, Stephan K Grant, T M Kelly, K K Wong.
Abstract
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.Entities:
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Year: 2004 PMID： 15357988 DOI： 10.1016/j.bmcl.2004.06.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823