Literature DB >> 15357982

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase.

Deane M Nason1, Steven D Heck, Mathew S Bodenstein, John A Lowe, Robert B Nelson, Dane R Liston, Charles E Nolan, Lorraine F Lanyon, Karen M Ward, Robert A Volkmann.   

Abstract

The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl)-pyridin-2-ylamines 1-8 are described. These compounds are potent inhibitors of the human nNOS isoform.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15357982     DOI： 10.1016/j.bmcl.2004.06.043

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.

Authors:  Maris A Cinelli; Huiying Li; Anthony V Pensa; Soosung Kang; Linda J Roman; Pavel Martásek; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2015-10-27       Impact factor: 7.446

Review 2.  Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.

Authors:  Paramita Mukherjee; Maris A Cinelli; Soosung Kang; Richard B Silverman
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

3.  A cellular model for screening neuronal nitric oxide synthase inhibitors.

Authors:  Jianguo Fang; Richard B Silverman
Journal:  Anal Biochem       Date:  2009-04-09       Impact factor: 3.365
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.