| Literature DB >> 15357976 |
Rocío Sancho1, Manuel Medarde, Sonsoles Sánchez-Palomino, Blanca M Madrigal, José Alcamí, Eduardo Muñoz, Arturo San Feliciano.
Abstract
The evaluation of the anti-HIV-1 activity of synthetic lignanolides and their intermediates is reported. The antiviral activity was studied through luciferase-based assays targeting the HIV-1 promoter activation induced by either, the HIV-1 Tat protein or the cellular transcription factor NF-kappaB, both known as crucial factors in HIV-1 replication. Among the compounds tested, three of them 2, 4 and 13 were further analysed for their anti-HIV-1 activity by recombinant virus assays, showing a suitable profile for development of novel anti-HIV-1 drugs.Entities:
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Year: 2004 PMID： 15357976 DOI： 10.1016/j.bmcl.2004.06.047
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823