| Literature DB >> 15357975 |
Piyasena Hewawasam1, Wenhong Fan, Deborah A Cook, Kimberly S Newberry, Christopher G Boissard, Valentin K Gribkoff, John Starrett, Nicholas J Lodge.
Abstract
A novel series of 4-aryl-3-(mercapto)quinolin-2-one derivatives was prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on corporal smooth muscle was studied in vitro using isolated rabbit corpus cavernosum. In vivo efficacy has been demonstrated with a selective maxi-K opening relaxant in a rat model of erectile function.Entities:
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Year: 2004 PMID： 15357975 DOI： 10.1016/j.bmcl.2004.06.051
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823