| Literature DB >> 15357962 |
Tuan P Tran1, Edmund L Ellsworth, Michael A Stier, John M Domagala, H D Showalter, Stephen J Gracheck, Martin A Shapiro, Themis E Joannides, Rajeshwar Singh.
Abstract
A series of 3-hydroxyquinazoline-2,4-diones was synthesized and evaluated for antibacterial activity. This series represents a novel addition to the DNA gyrase inhibitor class of antibacterials. Appropriate substitutions onto the core template yielded compounds with excellent potency against E. coli gyrase and significant in vitro Gram-negative and Gram-positive antibacterial activity.Entities:
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Year: 2004 PMID： 15357962 DOI： 10.1016/j.bmcl.2004.06.063
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823