| Literature DB >> 15357961 |
Paulo G Lima1, Rodrigo R B Caruso, Simone O Alves, Renata F Pessôa, Dayde L Mendonça-Silva, Ricardo J Nunes, François Noël, Newton G Castro, Paulo R R Costa.
Abstract
New N-heteroarylcarbonylalanines of the D-series were stereoselectively prepared from enoates derived from D-mannitol. These compounds were active in binding and functional assays of the NMDA sub-type of glutamate receptors. A pyridine derivative inhibited MK801 binding, protected neurons from excitotoxic damage and blocked NMDA-induced currents in neurons. A thiophene derivative positively modulated the NMDA receptor, possibly through the allosteric glycine site.Entities:
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Year: 2004 PMID： 15357961 DOI： 10.1016/j.bmcl.2004.06.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823