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Literature DB >> 15357612

A facile synthesis of C2,N3-disubstituted-4-quinazolone.

Song Xue¹, Joseph McKenna, Wen-Chung Shieh, Oljan Repic.

Abstract

A simple and efficient methodology for the synthesis of C(2),N(3)-disubstituted-4 quinazolones from anilines and N-acylanthranilic acids was developed. The new cyclization conditions are much milder than any other reported protocols and resulted in excellent yields (87-98%) without chromatography.

Entities: Chemical

Year: 2004 PMID： 15357612 DOI： 10.1021/jo049118e

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

3 in total

1. One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.

Authors: Chad E Schroeder; Sarah A Neuenswander; Tuanli Yao; Jeffrey Aubé; Jennifer E Golden
Journal: Org Biomol Chem Date: 2016-04-06 Impact factor: 3.876

2. A novel superparamagnetic powerful guanidine-functionalized γ-Fe₂O₃ based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media.

Authors: Fateme Haji Norouzi; Naser Foroughifar; Alireza Khajeh-Amiri; Hoda Pasdar
Journal: RSC Adv Date: 2021-09-07 Impact factor: 3.361

3. Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted.

Authors: Marcia Pérez-Fehrmann; Víctor Kesternich; Arturo Puelles; Víctor Quezada; Fernanda Salazar; Philippe Christen; Jonathan Castillo; Juan Guillermo Cárcamo; Alejandro Castro-Alvarez; Ronald Nelson
Journal: RSC Adv Date: 2022-08-02 Impact factor: 4.036

3 in total

A facile synthesis of C2,N3-disubstituted-4-quinazolone.

1. One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.

2. A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3 based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media.

3. Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted.

2. A novel superparamagnetic powerful guanidine-functionalized γ-Fe₂O₃ based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media.