Literature DB >> 1535595

The glycine-site NMDA receptor antagonist, R-(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one, L-687,414 is anticonvulsant in baboons.

S E Smith1, B S Meldrum.   

Abstract

The glycine-site NMDA receptor antagonist, R-(+)cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one (L-687,414) was administered i.t. to photosensitive baboons. The anticonvulsant action of L-687,414 (5-45 mg kg-1) was dose-dependent and peaked between 15 min and 2 h after administration. Gross behavioural effects were not observed at the doses tested. L-687,414 is a potent systemically acting anticonvulsant apparently devoid of serious side effects.

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Year:  1992        PMID： 1535595     DOI： 10.1016/0014-2999(92)90270-e

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

Review 1.  Antiepileptic drugs and mechanisms of epileptogenesis. A review.

Authors:  R Mutani; R Cantello; M Gianelli; C Civardi
Journal:  Ital J Neurol Sci       Date:  1995-05

2.  The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey.

Authors:  Donnie Eddins; Terence G Hamill; Vanita Puri; Christopher E Cannon; Jeffrey A Vivian; Sandra M Sanabria-Bohórquez; Jacquelynn J Cook; John A Morrow; Fiona Thomson; Jason M Uslaner
Journal:  Psychopharmacology (Berl)       Date:  2013-09-20       Impact factor: 4.530

3.  Lack of effect of L-687,414 ((+)-cis-4-methyl-HA-966), an NMDA receptor antagonist acting at the glycine site, on cerebral glucose metabolism and cortical neuronal morphology.

Authors:  R J Hargreaves; M Rigby; D Smith; R G Hill
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

4.  The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.

Authors:  M D Tricklebank; L J Bristow; P H Hutson; P D Leeson; M Rowley; K Saywell; L Singh; F D Tattersall; L Thorn; B J Williams
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739
  4 in total

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