PURPOSE: Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma. EXPERIMENTAL DESIGN: p16 protein expression was evaluated by immunohistochemistry in a tissue microarray composed of 123 oropharyngeal squamous cell cancers with a mean patient follow-up time of 33 months. RESULTS: p16 overexpression was associated with more advanced Tumor-Node-Metastasis stage and higher histologic grade. Despite this association with unfavorable features, p16 overexpression was associated with decreased 5-year local recurrence rates (11 versus 53%) and increased 5-year disease-free survival (62 versus 19%) and overall survival (60 versus 21%). In multivariate analysis, p16 expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival. CONCLUSIONS: In patients with oropharyngeal squamous cell carcinoma, overexpression of p16 as determined by immunohistochemistry is associated with significantly improved prognosis and lower local recurrence rates.
PURPOSE: Functional inactivation of p16 is an early and frequent event in head and neck squamous cell cancers. In this study, we sought to determine whether p16 expression is of prognostic importance in oropharyngeal squamous cell carcinoma. EXPERIMENTAL DESIGN:p16 protein expression was evaluated by immunohistochemistry in a tissue microarray composed of 123 oropharyngeal squamous cell cancers with a mean patient follow-up time of 33 months. RESULTS:p16 overexpression was associated with more advanced Tumor-Node-Metastasis stage and higher histologic grade. Despite this association with unfavorable features, p16 overexpression was associated with decreased 5-year local recurrence rates (11 versus 53%) and increased 5-year disease-free survival (62 versus 19%) and overall survival (60 versus 21%). In multivariate analysis, p16 expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival. CONCLUSIONS: In patients with oropharyngeal squamous cell carcinoma, overexpression of p16 as determined by immunohistochemistry is associated with significantly improved prognosis and lower local recurrence rates.
Authors: James S Lewis; Wade L Thorstad; Rebecca D Chernock; Bruce H Haughey; James H Yip; Qin Zhang; Samir K El-Mofty Journal: Am J Surg Pathol Date: 2010-08 Impact factor: 6.394
Authors: James S Lewis; Raja A Khan; Ramya P Masand; Rebecca D Chernock; Qin Zhang; Nasser Said Al-Naief; Susan Muller; Jonathan B McHugh; Manju L Prasad; Margaret Brandwein-Gensler; Bayardo Perez-Ordonez; Samir K El-Mofty Journal: Histopathology Date: 2011-12-23 Impact factor: 5.087
Authors: James S Lewis; William H Westra; Lester D R Thompson; Leon Barnes; Antonio Cardesa; Jennifer L Hunt; Michelle D Williams; Pieter J Slootweg; Asterios Triantafyllou; Julia A Woolgar; Kenneth O Devaney; Alessandra Rinaldo; Alfio Ferlito Journal: Head Neck Pathol Date: 2013-12-14
Authors: Tania Rodríguez-Santamarta; Juan Pablo Rodrigo; Juana M García-Pedrero; Saúl Álvarez-Teijeiro; M Ángeles Villaronga; Laura Suárez-Fernández; Marta E Alvarez-Argüelles; Aurora Astudillo; Juan Carlos de Vicente Journal: Eur Arch Otorhinolaryngol Date: 2016-06-24 Impact factor: 2.503