| Literature DB >> 15355089 |
Lishan Zhao1, Bin Han, Zilin Huang, Mark Miller, Hongjun Huang, Dan S Malashock, Zuolin Zhu, Aileen Milan, Dan E Robertson, David P Weiner, Mark J Burk.
Abstract
The discovery, from nature, of a diverse set of microbial epoxide hydrolases is reported. The utility of a library of epoxide hydrolases in the synthesis of chiral 1,2-diols via desymmetrization of a wide range of meso-epoxides, including cyclic as well as acyclic alkyl- and aryl-substituted substrates, is demonstrated. The chiral (R,R)-diols were furnished with high ee's and yields. The discovery of the first microbial epoxide hydrolases providing access to complementary (S,S)-diols is also described.Entities:
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Year: 2004 PMID： 15355089 DOI： 10.1021/ja0466210
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419