| Literature DB >> 15354397 |
A Beister1, P Kraus, W Kuhn, M Dose, A Weindl, M Gerlach.
Abstract
According to the excitotoxicity hypothesis, neurotoxicity due to glutamate is regarded as potential factor in the progredient neurodegeneration of Huntington's disease (HD). Memantine, as a glutamate receptor antagonist, should counteract this mechanism. Its effectiveness (up to 30 mg/day) with regard to retardation of progression was thus examined in 27 HD patients in a two year, open and multicentre trial. The results suggest that memantine treatment of HD may be useful in terms of retardation of the progression of the disorder.Entities:
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Year: 2004 PMID： 15354397 DOI： 10.1007/978-3-7091-0579-5_14
Source DB: PubMed Journal: J Neural Transm Suppl ISSN： 0303-6995